Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| LaDainian Tomlinson | HOU | 423 | 2481 | 5.9 | 63 | 17 | 117 | 7 | 8 | 2 | 1 |
| Larry Johnson | SFR | 427 | 2195 | 5.1 | 47 | 22 | 115 | 2 | 6 | 4 | 2 |
| Frank Gore | ATL | 415 | 2136 | 5.1 | 61 | 16 | 91 | 2 | 2 | 6 | 1 |
| Tiki Barber Tiki Barber | SEA | 425 | 2132 | 5.0 | 55 | 17 | 114 | 4 | 6 | 1 | 0 |
| Shaun Alexander | BUF | 431 | 2008 | 4.7 | 33 | 7 | 105 | 4 | 6 | 10 | 7 |
| Willie Parker | PIT | 363 | 1997 | 5.5 | 76 | 14 | 85 | 2 | 2 | 5 | 2 |
| Julius Jones | PHI | 382 | 1782 | 4.7 | 77 | 10 | 86 | 4 | 6 | 1 | 1 |
| Joseph Addai | MIN | 314 | 1563 | 5.0 | 41 | 5 | 78 | 4 | 4 | 5 | 4 |
| Brian Westbrook | SDI | 366 | 1501 | 4.1 | 43 | 12 | 73 | 2 | 3 | 4 | 3 |
| Fred Taylor | CHI | 301 | 1406 | 4.7 | 60 | 6 | 68 | 0 | 0 | 3 | 3 |
| Tatum Bell | NYG | 319 | 1304 | 4.1 | 51 | 3 | 68 | 5 | 5 | 3 | 2 |
| Willis McGahee | BAL | 306 | 1296 | 4.2 | 42 | 7 | 62 | 1 | 3 | 4 | 2 |
| Steven Jackson | JAX | 323 | 1265 | 3.9 | 58 | 7 | 64 | 5 | 8 | 5 | 1 |
| Corey Dillon | TEN | 265 | 1253 | 4.7 | 35 | 19 | 76 | 6 | 9 | 5 | 3 |
| Thomas Jones | DET | 315 | 1245 | 4.0 | 34 | 9 | 63 | 0 | 1 | 3 | 1 |
| Michael Turner | IND | 222 | 1163 | 5.2 | 25 | 12 | 61 | 1 | 1 | 2 | 2 |
| DeShaun Foster | NYJ | 263 | 1143 | 4.3 | 43 | 6 | 55 | 4 | 5 | 4 | 4 |
| Mike S. Bell | TBA | 210 | 1015 | 4.8 | 35 | 7 | 46 | 1 | 1 | 4 | 3 |
| Jamal Lewis | KCI | 260 | 1009 | 3.9 | 27 | 7 | 49 | 2 | 2 | 2 | 2 |
| Rudi Johnson | DAL | 238 | 1002 | 4.2 | 21 | 3 | 52 | 2 | 3 | 3 | 3 |
| Warrick Dunn | NEN | 210 | 916 | 4.4 | 22 | 6 | 49 | 2 | 2 | 3 | 1 |
| Justin Fargas | STL | 223 | 887 | 4.0 | 48 | 2 | 40 | 2 | 2 | 2 | 0 |
| Laurence Maroney | OAK | 199 | 853 | 4.3 | 41 | 6 | 48 | 3 | 4 | 1 | 1 |
| Wali Lundy | IND | 184 | 788 | 4.3 | 27 | 5 | 32 | 0 | 0 | 0 | 0 |
| Maurice Jones-Drew | NEN | 132 | 756 | 5.7 | 48 | 1 | 25 | 0 | 0 | 3 | 1 |
| Chester Taylor | OAK | 176 | 730 | 4.1 | 80 | 8 | 29 | 0 | 2 | 3 | 2 |
| Deuce McAllister | DET | 158 | 727 | 4.6 | 57 | 3 | 37 | 0 | 0 | 1 | 0 |
| Reggie Bush | GBA | 196 | 714 | 3.6 | 18 | 3 | 30 | 0 | 1 | 5 | 3 |
| Clinton Portis | TBA | 206 | 697 | 3.4 | 38 | 7 | 58 | 2 | 5 | 2 | 1 |
| Brandon Jacobs | NYG | 146 | 668 | 4.6 | 16 | 6 | 40 | 1 | 4 | 1 | 0 |
| Marion Barber III | STL | 128 | 597 | 4.7 | 25 | 3 | 28 | 0 | 0 | 1 | 0 |
| DeAngelo Williams | GBA | 121 | 543 | 4.5 | 28 | 5 | 26 | 1 | 1 | 1 | 0 |
| Cedric Benson | CHI | 118 | 492 | 4.2 | 30 | 3 | 34 | 1 | 1 | 1 | 0 |
| Ronnie Brown | TEN | 92 | 462 | 5.0 | 27 | 1 | 27 | 0 | 0 | 0 | 0 |
| Leon Washington | SDI | 91 | 371 | 4.1 | 20 | 2 | 19 | 0 | 0 | 0 | 0 |
| LenDale White | NYJ | 99 | 351 | 3.5 | 26 | 2 | 26 | 2 | 3 | 0 | 0 |
| Kevin Jones | DAL | 80 | 308 | 3.8 | 16 | 3 | 12 | 1 | 1 | 3 | 1 |
| David Garrard | DET | 54 | 264 | 4.9 | 18 | 1 | 11 | 0 | 0 | 2 | 1 |
| Vince Young | NYJ | 35 | 255 | 7.3 | 20 | 1 | 11 | 0 | 1 | 1 | 1 |
| Donovan McNabb | DAL | 54 | 250 | 4.6 | 37 | 3 | 13 | 1 | 1 | 4 | 2 |
| Ahman Green | SEA | 64 | 245 | 3.8 | 27 | 4 | 17 | 0 | 0 | 0 | 0 |
| Sammy Morris | BAL | 56 | 221 | 3.9 | 44 | 1 | 15 | 2 | 6 | 4 | 4 |
| Edgerrin James | STL | 69 | 220 | 3.2 | 18 | 1 | 20 | 2 | 2 | 2 | 1 |
| Kevan Barlow | MIN | 60 | 218 | 3.6 | 12 | 3 | 13 | 0 | 0 | 0 | 0 |
| Ladell Betts | SFR | 54 | 214 | 4.0 | 25 | 3 | 12 | 0 | 0 | 2 | 0 |
| Steve McNair | MIN | 58 | 211 | 3.6 | 19 | 5 | 21 | 5 | 5 | 3 | 1 |
| Jeremi Johnson | DAL | 40 | 181 | 4.5 | 15 | 4 | 19 | 0 | 0 | 1 | 0 |
| Maurice Morris | HOU | 34 | 143 | 4.2 | 17 | 2 | 9 | 0 | 0 | 0 | 0 |
| Cecil Sapp | CHI | 22 | 136 | 6.2 | 20 | 1 | 5 | 0 | 0 | 0 | 0 |
| Jeff Garcia | NYJ | 41 | 113 | 2.8 | 10 | 2 | 7 | 0 | 0 | 13 | 4 |
| Tom Brady | PHI | 40 | 103 | 2.6 | 11 | 0 | 5 | 2 | 3 | 10 | 6 |
| Matt Leinart | KCI | 40 | 98 | 2.5 | 9 | 3 | 10 | 4 | 4 | 10 | 6 |
| Jim Finn | TBA | 36 | 94 | 2.6 | 12 | 4 | 17 | 3 | 5 | 1 | 1 |
| Ben Roethlisberger | JAX | 21 | 93 | 4.4 | 20 | 1 | 7 | 1 | 1 | 0 | 0 |
| David Carr | TEN | 41 | 93 | 2.3 | 16 | 1 | 5 | 1 | 1 | 16 | 6 |
| LaMont Jordan | TBA | 27 | 92 | 3.4 | 9 | 0 | 5 | 0 | 0 | 0 | 0 |
| Ovie Mughelli | IND | 39 | 92 | 2.4 | 12 | 2 | 13 | 2 | 3 | 8 | 3 |
| Mike Alstott | TEN | 34 | 90 | 2.6 | 15 | 2 | 13 | 3 | 3 | 0 | 0 |
| J.P. Losman | CHI | 66 | 81 | 1.2 | 9 | 7 | 19 | 7 | 9 | 10 | 5 |
| Jason Campbell | IND | 19 | 77 | 4.1 | 10 | 1 | 3 | 0 | 1 | 1 | 0 |
| Cadillac Williams | IND | 20 | 76 | 3.8 | 12 | 1 | 4 | 0 | 0 | 0 | 0 |
| Jon Kitna | OAK | 19 | 68 | 3.6 | 17 | 0 | 6 | 3 | 4 | 7 | 4 |
| Chad Pennington | NYG | 26 | 64 | 2.5 | 11 | 1 | 3 | 0 | 0 | 1 | 0 |
| Anthony Thomas | STL | 24 | 63 | 2.6 | 8 | 3 | 8 | 0 | 0 | 0 | 0 |
| Philip Rivers | NEN | 28 | 56 | 2.0 | 15 | 0 | 7 | 4 | 5 | 2 | 1 |
| Heath Evans | ATL | 16 | 52 | 3.3 | 8 | 1 | 4 | 0 | 0 | 0 | 0 |
| Mack Strong | SEA | 18 | 52 | 2.9 | 14 | 0 | 5 | 1 | 2 | 2 | 1 |
| Reuben Droughns | GBA | 27 | 49 | 1.8 | 13 | 3 | 8 | 1 | 1 | 0 | 0 |
| Cedric Houston | NYG | 32 | 46 | 1.4 | 6 | 12 | 13 | 1 | 2 | 0 | 0 |
| Daunte Culpepper | STL | 38 | 45 | 1.2 | 8 | 0 | 4 | 2 | 4 | 7 | 2 |
| Tony Romo | TBA | 26 | 37 | 1.4 | 7 | 0 | 2 | 1 | 1 | 12 | 8 |
| Verron Haynes | NYG | 13 | 36 | 2.8 | 8 | 5 | 6 | 0 | 0 | 0 | 0 |
| Jason Wright | GBA | 7 | 22 | 3.1 | 17 | 0 | 1 | 0 | 0 | 0 | 0 |
| Dan Kreider | KCI | 4 | 20 | 5.0 | 9 | 0 | 3 | 1 | 1 | 0 | 0 |
| Reggie Brown | MIN | 1 | 19 | 19.0 | 19 | 0 | 1 | 0 | 0 | 2 | 0 |
| Najeh Davenport | PIT | 4 | 19 | 4.8 | 14 | 2 | 3 | 0 | 0 | 0 | 0 |
| Marc Bulger | SEA | 32 | 18 | 0.6 | 9 | 3 | 5 | 0 | 2 | 5 | 1 |
| Brett Favre | GBA | 35 | 18 | 0.5 | 10 | 0 | 8 | 3 | 5 | 4 | 4 |
| Zack Crockett | KCI | 1 | 16 | 16.0 | 16 | 0 | 1 | 1 | 1 | 0 | 0 |
| Aveion Cason | ATL | 3 | 15 | 5.0 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
| Ron Dayne | TEN | 3 | 14 | 4.7 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
| Justin Griffith | NEN | 5 | 14 | 2.8 | 7 | 1 | 1 | 0 | 0 | 6 | 4 |
| Travis Henry | NEN | 10 | 13 | 1.3 | 5 | 3 | 3 | 0 | 0 | 1 | 1 |
| Chris A. Brown | ATL | 2 | 12 | 6.0 | 7 | 0 | 1 | 1 | 1 | 0 | 0 |
| Earnest Graham | DET | 6 | 12 | 2.0 | 9 | 0 | 1 | 0 | 0 | 0 | 0 |
| Carson Palmer | SFR | 42 | 12 | 0.3 | 6 | 0 | 1 | 0 | 0 | 11 | 2 |
| T.J. Duckett | BAL | 5 | 11 | 2.2 | 6 | 2 | 3 | 0 | 0 | 0 | 0 |
| LaBrandon Toefield | HOU | 1 | 10 | 10.0 | 10 | 0 | 1 | 0 | 0 | 0 | 0 |
| Tim Rattay | BAL | 13 | 10 | 0.8 | 5 | 0 | 0 | 0 | 1 | 8 | 6 |
| Rex Grossman | SDI | 26 | 10 | 0.4 | 7 | 3 | 4 | 0 | 1 | 3 | 1 |
| Kyle Boller | IND | 24 | 9 | 0.4 | 5 | 0 | 4 | 1 | 2 | 6 | 2 |
| Arlen Harris | BUF | 4 | 5 | 1.3 | 4 | 2 | 2 | 0 | 0 | 0 | 0 |
| Mark Brunell | JAX | 9 | 5 | 0.6 | 8 | 0 | 0 | 0 | 0 | 2 | 1 |
| Santonio Holmes | PIT | 1 | 4 | 4.0 | 4 | 0 | 0 | 0 | 0 | 1 | 0 |
| Vernand Morency | NYG | 2 | 4 | 2.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Terrelle Smith | SDI | 7 | 4 | 0.6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Eli Manning | TEN | 2 | 3 | 1.5 | 3 | 0 | 0 | 0 | 0 | 1 | 1 |
| Peyton Manning | ATL | 11 | 3 | 0.3 | 5 | 0 | 0 | 0 | 0 | 2 | 1 |
| Mike Sellers | PIT | 1 | 1 | 1.0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Jamie Martin | PHI | 2 | 1 | 0.5 | 2 | 0 | 0 | 0 | 0 | 1 | 1 |
| Drew Brees | HOU | 29 | 1 | 0.0 | 10 | 0 | 1 | 0 | 0 | 3 | 2 |
| Oliver Hoyte | BUF | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Correll Buckhalter | KCI | 3 | 0 | 0.0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Jay Cutler | BUF | 27 | 0 | 0.0 | 1 | 0 | 3 | 0 | 2 | 22 | 14 |
| Stephen Davis | PHI | 2 | 0 | 0.0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| ReShard Lee | DAL | 2 | -1 | -0.5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Tony Fisher | BUF | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jake Plummer | DET | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Adrian Peterson | NYJ | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Cleo Lemon | SFR | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kellen Clemens | DAL | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Derek Anderson | SEA | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bruce Gradkowski | GBA | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Samkon Gado | MIN | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Drew Carter | SDI | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Eddie Kennison | IND | 2 | -7 | -3.5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Donte' Stallworth | DAL | 1 | -7 | -7.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Chris Henry | PHI | 1 | -7 | -7.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jake Delhomme | PIT | 32 | -14 | -0.4 | 5 | 1 | 2 | 0 | 1 | 5 | 2 |
| Sum | --- | 10793 | 46238 | --- | 2255 | 370 | 2482 | 126 | 190 | 308 | 158 |
| Avg | --- | 91 | 389 | --- | 19 | 3 | 21 | 1 | 2 | 3 | 1 |