Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Warren Sapp | PIT | Left Tackle | 14 | 102 |
| Shaun Phillips | HOU | Left O LB | 13 | 94 |
| Luis Castillo | HOU | Left End | 12 | 87 |
| Chike Okeafor | BAL | Left End | 11 | 87 |
| Aaron Schobel | SFR | Right End | 11 | 78 |
| Ebenezer Ekuban | SEA | Right End | 11 | 75 |
| Jason Taylor | DET | Right End | 11 | 72 |
| Kevin Carter | ATL | Left End | 9 | 64 |
| Bryan Thomas | PIT | Right O LB | 9 | 64 |
| Will Smith | TEN | Right End | 9 | 59 |
| Julius Peppers | HOU | Left End | 8 | 63 |
| Derrick Johnson | NYJ | Left LB | 8 | 61 |
| Julian Peterson | SEA | Right LB | 8 | 56 |
| Aaron Kampman | DAL | Left End | 8 | 51 |
| Shawne Merriman | BAL | Right O LB | 8 | 43 |
| Richard Seymour | IND | Right End | 8 | 35 |
| Corey Williams | DAL | Left Tackle | 8 | 31 |
| Ryan Denney | PHI | Def End | 7 | 51 |
| Kyle Vanden Bosch | NEN | Left End | 7 | 51 |
| Leonard Little | CHI | Left End | 7 | 48 |
| DeMarcus Ware | BUF | Right O LB | 7 | 45 |
| Mark Anderson | DAL | Def End | 6 | 46 |
| Alex Brown | DET | Right End | 6 | 41 |
| Grant Wistrom | MIN | Right End | 6 | 40 |
| Trevor Pryce | SDI | Left End | 6 | 37 |
| Justin Smith | GBA | Right End | 6 | 36 |
| Terrell Suggs | SDI | Right End | 6 | 32 |
| Ernie Sims | HOU | Right LB | 6 | 29 |
| Eric Barton | SDI | Left O LB | 5 | 40 |
| Jamal Williams | GBA | Nose Tackle | 5 | 38 |
| Keith Lewis | BUF | Free Safety | 5 | 36 |
| Robert Geathers | SDI | Def End | 5 | 36 |
| John Lynch | ATL | Free Safety | 5 | 35 |
| Dwight Freeney | NYG | Right End | 5 | 34 |
| Vonnie Holliday | DET | Right Tackle | 5 | 32 |
| Brian Russell | HOU | Free Safety | 5 | 32 |
| Brian Young | MIN | Left Tackle | 5 | 31 |
| Jared Allen | BUF | Right End | 5 | 29 |
| Will Witherspoon | DAL | Middle LB | 5 | 27 |
| Hollis Thomas | MIN | Right Tackle | 5 | 26 |
| Brian Urlacher | PIT | Middle LB | 5 | 23 |
| Kris Jenkins | SFR | Right Tackle | 5 | 19 |
| Casey Hampton | CHI | Nose Tackle | 5 | 13 |
| Cory Redding | IND | Right Tackle | 4 | 36 |
| Ty Warren | TEN | Left End | 4 | 32 |
| Kenard Lang | NYJ | Left End | 4 | 30 |
| Darrion Scott | NYJ | Left End | 4 | 29 |
| Derrick Burgess | JAX | Right End | 4 | 28 |
| Bobby McCray | NYG | Left End | 4 | 26 |
| Osi Umenyiora | TBA | Right End | 4 | 26 |
| Karlos Dansby | IND | Left LB | 4 | 25 |
| Grady Jackson | HOU | Left Tackle | 4 | 22 |
| Scott Fujita | TEN | Left LB | 4 | 20 |
| Kevin Williams | NYG | Right Tackle | 4 | 18 |
| Darnell Dockett | ATL | Right Tackle | 4 | 17 |
| Chartric Darby | NYJ | Left Tackle | 4 | 17 |
| Ray Lewis | SEA | Middle LB | 4 | 17 |
| Keith Traylor | PIT | Left Tackle | 4 | 17 |
| Junior Seau | NYG | Left I LB | 4 | 12 |
| Adewale Ogunleye | TBA | Left End | 3 | 30 |
| Brandon Chillar | IND | Left LB | 3 | 27 |
| Greg Spires | PHI | Left End | 3 | 25 |
| Bryce Fisher | NEN | Left End | 3 | 25 |
| Kamerion Wimbley | STL | Right O LB | 3 | 23 |
| John Henderson | TEN | Right Tackle | 3 | 23 |
| Roderick Coleman | TBA | Right Tackle | 3 | 21 |
| Mike Rucker | SEA | Right End | 3 | 20 |
| Clark Haggans | PIT | Left O LB | 3 | 20 |
| Keith Brooking | SFR | Right LB | 3 | 20 |
| Charles Grant | SFR | Left End | 3 | 19 |
| Simon Fraser | BAL | Def End | 3 | 18 |
| Artrell Hawkins | PHI | Free Safety | 3 | 17 |
| Stanford Routt | TBA | 1st Defensive Back | 3 | 14 |
| Michael Myers | BAL | Left Tackle | 3 | 14 |
| Marques Douglas | BAL | Right Tackle | 3 | 8 |
| Damione Lewis | BUF | Def Tackle | 3 | 7 |
| Lofa Tatupu | NYJ | Middle LB | 3 | 3 |
| Antonio Pierce | KCI | Middle LB | 3 | 0 |
| Danieal Manning | DET | Free Safety | 2 | 21 |
| Joey Porter | GBA | Right O LB | 2 | 19 |
| Mike McKenzie | PIT | Left CB | 2 | 18 |
| Travis LaBoy | STL | Right End | 2 | 18 |
| Marcus Bell | TEN | Left Tackle | 2 | 17 |
| Willie McGinest | PHI | Left O LB | 2 | 17 |
| Bernard Pollard | TEN | 1st Defensive Back | 2 | 17 |
| Ed Reed | NYG | Free Safety | 2 | 17 |
| Thomas Davis | CHI | Left LB | 2 | 16 |
| Shelton Quarles | HOU | Middle LB | 2 | 16 |
| DeAngelo Hall | SFR | Left CB | 2 | 15 |
| Lamont Thompson | OAK | Free Safety | 2 | 15 |
| Angelo Crowell | TBA | Left LB | 2 | 15 |
| A.J. Hawk | CHI | Right LB | 2 | 14 |
| Brett Keisel | BUF | Right End | 2 | 13 |
| Ian Gold | PIT | Right LB | 2 | 13 |
| Kendrick Clancy | DET | Left Tackle | 2 | 12 |
| Elvis Dumervil | PIT | Def End | 2 | 12 |
| Michael Strahan | JAX | Left End | 2 | 12 |
| Greg Wesley | SFR | Free Safety | 2 | 11 |
| Shaun Ellis | MIN | Left End | 2 | 11 |
| Fred Robbins | JAX | Right Tackle | 2 | 11 |
| James Farrior | GBA | Left I LB | 2 | 10 |
| Tommie Harris | TBA | Left Tackle | 2 | 10 |
| Pat Williams | HOU | Left Tackle | 2 | 10 |
| Ellis Wyms | OAK | Right Tackle | 2 | 9 |
| Kabeer Gbaja-Biamila | OAK | Right End | 2 | 9 |
| Dhani Jones | GBA | Left LB | 2 | 9 |
| Landon Johnson | DAL | Right LB | 2 | 9 |
| Darwin Walker | DET | Right Tackle | 2 | 8 |
| Chris Hoke | PHI | Nose Tackle | 2 | 7 |
| Victor Hobson | DET | Right I LB | 2 | 7 |
| Albert Haynesworth | STL | Right Tackle | 2 | 6 |
| Marcus Stroud | NYG | Left Tackle | 2 | 5 |
| Kelly Gregg | SEA | Left Tackle | 2 | 5 |
| Jonathan Vilma | JAX | Left I LB | 2 | 5 |
| Donnie Edwards | GBA | Right I LB | 2 | 3 |
| John Abraham | PIT | Right End | 1 | 12 |
| Gerard Warren | SFR | Right Tackle | 1 | 11 |
| Robert Mathis | IND | Left End | 1 | 11 |
| Keith Bulluck | ATL | Right LB | 1 | 10 |
| Manny Lawson | BUF | Left LB | 1 | 10 |
| Michael Huff | CHI | Strong Safety | 1 | 10 |
| Sean Considine | DAL | Strong Safety | 1 | 10 |
| Mike Patterson | HOU | Left Tackle | 1 | 9 |
| Marcus Washington | DET | Left LB | 1 | 9 |
| Paul Spicer | KCI | Right End | 1 | 9 |
| Patrick Surtain | DAL | Right CB | 1 | 9 |
| Rosevelt Colvin | NYG | Left O LB | 1 | 9 |
| La'Roi Glover | KCI | Left Tackle | 1 | 9 |
| Chris Hope | SFR | Strong Safety | 1 | 9 |
| Warrick Holdman | TEN | Right LB | 1 | 9 |
| O.J. Atogwe | NYJ | Free Safety | 1 | 8 |
| Charles Tillman | NYJ | Left CB | 1 | 8 |
| Antoine Winfield | SDI | Left CB | 1 | 7 |
| Andre Carter | CHI | Right End | 1 | 7 |
| Zach Thomas | BAL | Middle LB | 1 | 7 |
| Craig Terrill | DAL | Def Tackle | 1 | 7 |
| Chris Canty | STL | Right End | 1 | 7 |
| Russell Davis | HOU | Def Tackle | 1 | 7 |
| Yeremiah Bell | TEN | Strong Safety | 1 | 7 |
| Greg Ellis | STL | Left O LB | 1 | 6 |
| Bryant Young | OAK | Left End | 1 | 6 |
| Josh Bullocks | MIN | Free Safety | 1 | 6 |
| Andra Davis | PHI | Left I LB | 1 | 6 |
| Darren Sharper | NEN | Strong Safety | 1 | 6 |
| Tim Johnson | BUF | I LB | 1 | 6 |
| Kirk Morrison | SFR | Middle LB | 1 | 5 |
| Akin Ayodele | IND | Right I LB | 1 | 5 |
| Nick Barnett | STL | Middle LB | 1 | 5 |
| Aaron Smith | PIT | Left End | 1 | 5 |
| Donnie Spragan | MIN | Left LB | 1 | 5 |
| Dre' Bly | DET | Right CB | 1 | 4 |
| Adalius Thomas | BAL | Left LB | 1 | 4 |
| Na'il Diggs | DAL | Right LB | 1 | 4 |
| Anthony McFarland | CHI | Left Tackle | 1 | 3 |
| Carlos Emmons | JAX | Left LB | 1 | 3 |
| Chauncey Davis | ATL | Def End | 1 | 3 |
| Mike Vrabel | DET | Right O LB | 1 | 3 |
| Edgerton Hartwell | TEN | Middle LB | 1 | 3 |
| D'Qwell Jackson | DAL | Right I LB | 1 | 3 |
| Jonathan Babineaux | STL | Def Tackle | 1 | 1 |
| Anthony B. Smith | STL | 1st Defensive Back | 1 | 1 |
| Bobby Carpenter | BUF | I LB | 1 | 0 |
| London Fletcher-Baker | ATL | Middle LB | 1 | 0 |
| Chris Draft | NYJ | Middle LB | 1 | 0 |
| Ronald Fields | OAK | Left Tackle | 1 | 0 |
| Napoleon Harris | TBA | Middle LB | 1 | 0 |
| Kawika Mitchell | CHI | Middle LB | 1 | 0 |
| Sum | --- | --- | 558 | 3481 |
| Avg | --- | --- | 3 | 21 |