Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| Larry Johnson | GBA | 460 | 2332 | 5.1 | 40 | 20 | 107 | 3 | 4 | 2 | 2 |
| Frank Gore | SEA | 411 | 2118 | 5.2 | 54 | 17 | 95 | 3 | 3 | 4 | 3 |
| Fred Taylor | BUF | 373 | 2066 | 5.5 | 53 | 10 | 86 | 2 | 2 | 0 | 0 |
| Ladell Betts | PIT | 392 | 1959 | 5.0 | 26 | 7 | 94 | 0 | 0 | 7 | 2 |
| LaDainian Tomlinson | PHI | 383 | 1938 | 5.1 | 70 | 15 | 78 | 2 | 2 | 4 | 2 |
| Willie Parker | MIA | 394 | 1863 | 4.7 | 76 | 11 | 72 | 0 | 1 | 6 | 4 |
| Maurice Jones-Drew | CLE | 268 | 1629 | 6.1 | 74 | 6 | 77 | 0 | 2 | 7 | 7 |
| Thomas Jones | CIN | 378 | 1585 | 4.2 | 30 | 10 | 76 | 5 | 5 | 3 | 2 |
| Steven Jackson | JAX | 320 | 1455 | 4.5 | 37 | 5 | 71 | 1 | 3 | 4 | 3 |
| Jamal Lewis | DET | 334 | 1439 | 4.3 | 18 | 6 | 69 | 2 | 4 | 3 | 1 |
| Brian Westbrook | ARI | 290 | 1423 | 4.9 | 43 | 10 | 77 | 1 | 2 | 0 | 0 |
| Travis Henry | HOU | 249 | 1364 | 5.5 | 43 | 8 | 55 | 0 | 0 | 1 | 1 |
| Chester Taylor | BAL | 346 | 1364 | 3.9 | 68 | 9 | 74 | 7 | 8 | 1 | 1 |
| Leon Washington | SFR | 222 | 1253 | 5.6 | 23 | 5 | 52 | 0 | 0 | 5 | 2 |
| Joseph Addai | IND | 273 | 1168 | 4.3 | 29 | 7 | 51 | 0 | 0 | 7 | 2 |
| Mike S. Bell | MIN | 243 | 1148 | 4.7 | 48 | 4 | 54 | 2 | 2 | 4 | 2 |
| Justin Fargas | OAK | 288 | 1125 | 3.9 | 19 | 5 | 52 | 0 | 0 | 4 | 2 |
| Michael Turner | SDI | 192 | 1079 | 5.6 | 43 | 7 | 56 | 1 | 1 | 1 | 0 |
| Laurence Maroney | SDI | 204 | 1035 | 5.1 | 36 | 4 | 52 | 0 | 1 | 6 | 5 |
| Shaun Alexander | NYG | 218 | 921 | 4.2 | 27 | 3 | 46 | 2 | 5 | 8 | 6 |
| Tatum Bell | DEN | 184 | 874 | 4.8 | 51 | 3 | 33 | 0 | 0 | 3 | 1 |
| Warrick Dunn | DEN | 200 | 869 | 4.3 | 30 | 7 | 42 | 1 | 2 | 1 | 0 |
| Edgerrin James | DAL | 260 | 868 | 3.3 | 18 | 1 | 42 | 4 | 4 | 2 | 2 |
| Clinton Portis | NEN | 220 | 849 | 3.9 | 38 | 5 | 42 | 0 | 0 | 2 | 1 |
| Reggie Bush | CHI | 188 | 815 | 4.3 | 18 | 1 | 40 | 1 | 1 | 11 | 3 |
| Dominic Rhodes | NYJ | 207 | 734 | 3.5 | 17 | 9 | 39 | 5 | 8 | 4 | 2 |
| Jerious Norwood | DAL | 155 | 732 | 4.7 | 67 | 2 | 33 | 0 | 1 | 2 | 2 |
| Marion Barber III | NYJ | 181 | 717 | 4.0 | 25 | 2 | 40 | 2 | 2 | 1 | 0 |
| Brandon Jacobs | ARI | 164 | 710 | 4.3 | 16 | 7 | 58 | 3 | 4 | 2 | 0 |
| Deuce McAllister | CHI | 196 | 679 | 3.5 | 30 | 7 | 46 | 3 | 7 | 4 | 3 |
| LenDale White | NEN | 152 | 658 | 4.3 | 20 | 8 | 40 | 3 | 3 | 0 | 0 |
| DeAngelo Williams | NYG | 131 | 601 | 4.6 | 23 | 4 | 23 | 0 | 0 | 1 | 0 |
| Cedric Benson | OAK | 173 | 587 | 3.4 | 17 | 5 | 35 | 2 | 3 | 3 | 2 |
| Julius Jones | MIN | 117 | 540 | 4.6 | 52 | 8 | 22 | 0 | 1 | 1 | 1 |
| Ron Dayne | SFR | 79 | 319 | 4.0 | 18 | 0 | 30 | 0 | 0 | 0 | 0 |
| Kevan Barlow | CLE | 105 | 318 | 3.0 | 12 | 3 | 24 | 0 | 0 | 1 | 1 |
| Willis McGahee | PIT | 95 | 312 | 3.3 | 18 | 1 | 22 | 2 | 3 | 3 | 3 |
| Donovan McNabb | BUF | 51 | 297 | 5.8 | 37 | 3 | 13 | 0 | 0 | 2 | 0 |
| David Garrard | NYJ | 60 | 268 | 4.5 | 20 | 3 | 12 | 1 | 1 | 1 | 1 |
| Matt Hasselbeck | JAX | 37 | 250 | 6.8 | 19 | 0 | 10 | 1 | 1 | 6 | 4 |
| Maurice Morris | SFR | 48 | 243 | 5.1 | 29 | 0 | 9 | 0 | 0 | 0 | 0 |
| Sammy Morris | HOU | 71 | 239 | 3.4 | 18 | 10 | 27 | 4 | 6 | 1 | 0 |
| Reuben Droughns | IND | 72 | 227 | 3.2 | 22 | 2 | 12 | 0 | 0 | 1 | 1 |
| Ronnie Brown | CIN | 50 | 185 | 3.7 | 27 | 4 | 16 | 1 | 1 | 1 | 1 |
| Tony Romo | PIT | 56 | 160 | 2.9 | 13 | 5 | 14 | 1 | 3 | 10 | 5 |
| Cedric Houston | SFR | 60 | 159 | 2.7 | 14 | 10 | 24 | 4 | 8 | 0 | 0 |
| Tom Brady | HOU | 35 | 155 | 4.4 | 22 | 0 | 6 | 0 | 0 | 8 | 2 |
| Mike Anderson | SEA | 52 | 151 | 2.9 | 24 | 2 | 9 | 1 | 1 | 0 | 0 |
| Zack Crockett | OAK | 49 | 142 | 2.9 | 16 | 3 | 20 | 3 | 3 | 2 | 2 |
| Rudi Johnson | SDI | 26 | 135 | 5.2 | 22 | 1 | 11 | 2 | 2 | 1 | 1 |
| Chris A. Brown | BUF | 44 | 125 | 2.8 | 12 | 9 | 17 | 0 | 0 | 2 | 2 |
| Jon Kitna | PHI | 36 | 99 | 2.8 | 17 | 2 | 14 | 5 | 5 | 4 | 2 |
| Jason Wright | NYJ | 24 | 98 | 4.1 | 18 | 0 | 6 | 0 | 0 | 0 | 0 |
| Cadillac Williams | CHI | 17 | 89 | 5.2 | 38 | 0 | 4 | 0 | 1 | 0 | 0 |
| Ben Roethlisberger | OAK | 32 | 89 | 2.8 | 20 | 2 | 8 | 3 | 3 | 1 | 1 |
| Heath Evans | SEA | 27 | 85 | 3.1 | 18 | 4 | 8 | 0 | 0 | 1 | 1 |
| Correll Buckhalter | DEN | 15 | 78 | 5.2 | 16 | 0 | 6 | 0 | 0 | 1 | 0 |
| Chad Pennington | CIN | 39 | 76 | 1.9 | 11 | 4 | 9 | 1 | 1 | 2 | 2 |
| Steve McNair | SEA | 34 | 73 | 2.1 | 19 | 2 | 10 | 5 | 5 | 1 | 1 |
| LaMont Jordan | NEN | 23 | 70 | 3.0 | 13 | 0 | 5 | 1 | 1 | 0 | 0 |
| Dan Kreider | BUF | 29 | 64 | 2.2 | 9 | 9 | 14 | 2 | 2 | 1 | 0 |
| Philip Rivers | NYG | 16 | 59 | 3.7 | 15 | 1 | 4 | 0 | 1 | 5 | 1 |
| Vince Young | CHI | 22 | 58 | 2.6 | 8 | 0 | 3 | 0 | 0 | 0 | 0 |
| Justin Griffith | MIA | 17 | 50 | 2.9 | 18 | 0 | 6 | 0 | 2 | 5 | 5 |
| Patrick Crayton | DAL | 1 | 42 | 42.0 | 42 | 1 | 1 | 0 | 0 | 2 | 1 |
| Drew Brees | BAL | 18 | 41 | 2.3 | 16 | 0 | 2 | 1 | 1 | 4 | 0 |
| Anthony Thomas | DEN | 12 | 40 | 3.3 | 9 | 0 | 2 | 0 | 0 | 0 | 0 |
| David Carr | DEN | 38 | 40 | 1.1 | 16 | 1 | 10 | 1 | 2 | 5 | 3 |
| Vernand Morency | SFR | 27 | 39 | 1.4 | 6 | 8 | 12 | 0 | 1 | 0 | 0 |
| DeShaun Foster | BAL | 14 | 36 | 2.6 | 8 | 3 | 5 | 0 | 1 | 0 | 0 |
| Matt Leinart | CHI | 14 | 34 | 2.4 | 13 | 2 | 4 | 1 | 2 | 3 | 1 |
| Mike Karney | BAL | 14 | 33 | 2.4 | 9 | 1 | 6 | 0 | 0 | 0 | 0 |
| J.P. Losman | DEN | 26 | 31 | 1.2 | 12 | 2 | 3 | 0 | 1 | 11 | 3 |
| Trent Green | MIN | 5 | 29 | 5.8 | 8 | 0 | 3 | 0 | 0 | 1 | 0 |
| Ovie Mughelli | DET | 7 | 29 | 4.1 | 7 | 0 | 4 | 2 | 2 | 2 | 0 |
| Brett Favre | MIN | 30 | 29 | 1.0 | 12 | 2 | 11 | 3 | 6 | 6 | 1 |
| Isaac Bruce | MIN | 2 | 27 | 13.5 | 30 | 1 | 1 | 0 | 0 | 0 | 0 |
| Kevin Faulk | PHI | 10 | 25 | 2.5 | 11 | 0 | 1 | 0 | 1 | 3 | 2 |
| Andrew Pinnock | MIN | 2 | 21 | 10.5 | 15 | 0 | 1 | 0 | 0 | 0 | 0 |
| T.J. Duckett | DET | 7 | 21 | 3.0 | 8 | 0 | 2 | 0 | 0 | 0 | 0 |
| Carson Palmer | GBA | 28 | 21 | 0.8 | 6 | 1 | 2 | 0 | 1 | 8 | 4 |
| Mewelde Moore | MIA | 7 | 20 | 2.9 | 7 | 0 | 0 | 0 | 0 | 4 | 2 |
| Arlen Harris | SFR | 13 | 19 | 1.5 | 7 | 6 | 8 | 1 | 1 | 0 | 0 |
| Daunte Culpepper | CLE | 49 | 19 | 0.4 | 7 | 6 | 6 | 0 | 0 | 10 | 4 |
| Jeff Garcia | SDI | 2 | 15 | 7.5 | 10 | 0 | 1 | 0 | 0 | 0 | 0 |
| Brad Johnson | ARI | 11 | 14 | 1.3 | 10 | 1 | 3 | 0 | 1 | 2 | 1 |
| Najeh Davenport | JAX | 10 | 12 | 1.2 | 6 | 3 | 4 | 1 | 2 | 0 | 0 |
| Jay Cutler | DET | 31 | 12 | 0.4 | 4 | 2 | 9 | 5 | 5 | 23 | 11 |
| Marc Bulger | SDI | 17 | 11 | 0.6 | 5 | 3 | 4 | 0 | 0 | 3 | 2 |
| Donnie Jones | NYJ | 1 | 9 | 9.0 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kevin Jones | CHI | 2 | 9 | 4.5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ahman Green | ARI | 5 | 9 | 1.8 | 5 | 1 | 1 | 0 | 0 | 0 | 0 |
| Roddy White | CLE | 1 | 8 | 8.0 | 8 | 0 | 0 | 0 | 0 | 5 | 4 |
| Eli Manning | MIA | 28 | 8 | 0.3 | 8 | 0 | 5 | 2 | 3 | 9 | 6 |
| Josh Bidwell | MIA | 1 | 7 | 7.0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Shane Lechler | OAK | 1 | 7 | 7.0 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
| Lorenzo Neal | MIN | 12 | 7 | 0.6 | 4 | 2 | 3 | 0 | 1 | 1 | 1 |
| Brad Hoover | IND | 3 | 6 | 2.0 | 6 | 2 | 2 | 0 | 0 | 0 | 0 |
| Michael Pittman | DET | 3 | 6 | 2.0 | 5 | 2 | 2 | 0 | 0 | 0 | 0 |
| Kenny Watson | CIN | 8 | 6 | 0.8 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Adrian Peterson | HOU | 3 | 4 | 1.3 | 3 | 0 | 2 | 1 | 1 | 0 | 0 |
| Peyton Manning | NEN | 15 | 4 | 0.3 | 6 | 1 | 2 | 0 | 1 | 1 | 1 |
| Moran Norris | DAL | 1 | 3 | 3.0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| Seneca Wallace | JAX | 1 | 3 | 3.0 | 3 | 0 | 0 | 0 | 0 | 1 | 1 |
| Terrelle Smith | CIN | 2 | 3 | 1.5 | 3 | 0 | 1 | 0 | 1 | 0 | 0 |
| Cecil Sapp | NYJ | 2 | 2 | 1.0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
| Oliver Hoyte | MIA | 3 | 2 | 0.7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Verron Haynes | ARI | 4 | 2 | 0.5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kelly Holcomb | NYJ | 2 | 1 | 0.5 | 2 | 0 | 1 | 1 | 2 | 0 | 0 |
| Madison Hedgecock | GBA | 2 | 1 | 0.5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Matt Cassel | OAK | 4 | 1 | 0.3 | 3 | 0 | 0 | 0 | 0 | 1 | 0 |
| Ashley Lelie | OAK | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nick Harris | DEN | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Musa Smith | GBA | 6 | 0 | 0.0 | 3 | 0 | 0 | 0 | 0 | 1 | 0 |
| Alex D. Smith | BAL | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Derek Anderson | IND | 3 | 0 | 0.0 | 0 | 0 | 0 | 0 | 1 | 3 | 3 |
| Kurt Warner | ARI | 9 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 9 | 6 |
| Jason McKie | JAX | 3 | -1 | -0.3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chris Simms | SEA | 2 | -1 | -0.5 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| B.J. Askew | CLE | 2 | -1 | -0.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Michael Robinson | SEA | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Michael Bennett | IND | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chris Chambers | DET | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 |
| Kevin Curtis | CLE | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Plaxico Burress | JAX | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Greg Lewis | PIT | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Bryant Johnson | MIA | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
| Michael Jenkins | DET | 2 | -3 | -1.5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Ronald Curry | OAK | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
| Rex Grossman | IND | 15 | -4 | -0.3 | 3 | 2 | 3 | 1 | 1 | 4 | 2 |
| Randy Moss | OAK | 2 | -4 | -2.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Reggie Wayne | HOU | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
| Demetrius Williams | NYJ | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Joey Harrington | DAL | 24 | -5 | -0.2 | 5 | 1 | 3 | 1 | 1 | 2 | 0 |
| Joe Horn | PIT | 1 | -5 | -5.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Wes Welker | JAX | 3 | -8 | -2.7 | 0 | 0 | 0 | 0 | 0 | 4 | 0 |
| Jake Delhomme | SFR | 24 | -19 | -0.8 | 0 | 0 | 0 | 0 | 0 | 4 | 2 |
| Sum | --- | 10695 | 45865 | --- | 2246 | 373 | 2435 | 114 | 171 | 322 | 170 |
| Avg | --- | 78 | 335 | --- | 16 | 3 | 18 | 1 | 1 | 2 | 1 |