Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Derrick Burgess | CIN | Right End | 19 | 132 |
| Jared Allen | BUF | Right End | 16 | 121 |
| Shaun Phillips | CIN | Left O LB | 14 | 89 |
| Shawne Merriman | MIN | Right O LB | 12 | 85 |
| Aaron Kampman | SEA | Left End | 12 | 79 |
| Robert Geathers | OAK | Def End | 11 | 76 |
| Joey Porter | CIN | Right O LB | 10 | 80 |
| Julius Peppers | DEN | Left End | 10 | 69 |
| Julian Peterson | SEA | Right LB | 8 | 61 |
| Kenard Lang | SFR | Left End | 8 | 56 |
| Bryan Thomas | DET | Right O LB | 8 | 52 |
| Mark Anderson | BUF | Def End | 8 | 52 |
| Leonard Little | MIA | Left End | 8 | 38 |
| Warren Sapp | DEN | Left Tackle | 7 | 44 |
| Justin Smith | BAL | Right End | 7 | 43 |
| Tommy Kelly | OAK | Right Tackle | 7 | 42 |
| Jason Taylor | DAL | Right End | 6 | 48 |
| Luis Castillo | BAL | Left End | 6 | 48 |
| Will Smith | PHI | Right End | 6 | 47 |
| Adalius Thomas | MIA | Left LB | 6 | 44 |
| Kamerion Wimbley | PHI | Right O LB | 6 | 38 |
| Ty Warren | GBA | Left End | 6 | 38 |
| Cory Redding | SDI | Right Tackle | 6 | 36 |
| Kelly Gregg | NYJ | Left Tackle | 6 | 35 |
| Trevor Pryce | DEN | Left End | 6 | 35 |
| A.J. Hawk | BUF | Right LB | 6 | 30 |
| DeMeco Ryans | DAL | Middle LB | 6 | 17 |
| Andre Carter | JAX | Right End | 5 | 41 |
| Kyle Vanden Bosch | NYJ | Left End | 5 | 37 |
| Bertrand Berry | HOU | Right End | 5 | 31 |
| Alex Brown | ARI | Right End | 5 | 29 |
| Karlos Dansby | BUF | Left LB | 5 | 28 |
| Keith Traylor | HOU | Left Tackle | 5 | 26 |
| Darwin Walker | PHI | Right Tackle | 5 | 25 |
| Eric Barton | OAK | Left O LB | 5 | 19 |
| Pat Williams | NEN | Left Tackle | 5 | 11 |
| John Abraham | DET | Right End | 4 | 34 |
| John Lynch | NEN | Free Safety | 4 | 33 |
| London Fletcher-Baker | DEN | Middle LB | 4 | 30 |
| DeMarcus Ware | DAL | Right O LB | 4 | 30 |
| Greg Ellis | JAX | Left O LB | 4 | 29 |
| Cullen Jenkins | SDI | Def End | 4 | 29 |
| Richard Seymour | MIA | Right End | 4 | 26 |
| Trent Cole | DAL | Left End | 4 | 25 |
| Rosevelt Colvin | ARI | Left O LB | 4 | 24 |
| Darrion Scott | PIT | Left End | 4 | 24 |
| Keith Bulluck | DEN | Right LB | 4 | 24 |
| Tommie Harris | NYG | Left Tackle | 4 | 24 |
| Mario Williams | NYJ | Right End | 4 | 23 |
| Kris Jenkins | MIA | Right Tackle | 4 | 22 |
| Chartric Darby | DET | Left Tackle | 4 | 21 |
| Bart Scott | PHI | Right LB | 4 | 19 |
| Charles Grant | MIN | Left End | 4 | 19 |
| Vonnie Holliday | IND | Right Tackle | 4 | 18 |
| John Henderson | JAX | Right Tackle | 4 | 17 |
| Brett Keisel | CHI | Right End | 3 | 28 |
| Darren Sharper | JAX | Strong Safety | 3 | 26 |
| Brandon Chillar | ARI | Left LB | 3 | 24 |
| Clark Haggans | GBA | Left O LB | 3 | 23 |
| Kevin Williams | IND | Right Tackle | 3 | 23 |
| Shaun Ellis | IND | Left End | 3 | 23 |
| Kevin Carter | GBA | Left End | 3 | 23 |
| Aaron Schobel | IND | Right End | 3 | 22 |
| Michael Strahan | MIN | Left End | 3 | 22 |
| Robert Mathis | CIN | Left End | 3 | 21 |
| Bobby McCray | ARI | Left End | 3 | 21 |
| Brandon T. Moore | NEN | Right LB | 3 | 21 |
| Zach Thomas | MIA | Middle LB | 3 | 21 |
| Junior Seau | CIN | Left I LB | 3 | 21 |
| Manny Lawson | SDI | Left LB | 3 | 20 |
| Dwight Freeney | SDI | Right End | 3 | 19 |
| Aaron Smith | DEN | Left End | 3 | 18 |
| Sam Adams | SDI | Left Tackle | 3 | 18 |
| Anthony McFarland | DAL | Left Tackle | 3 | 17 |
| Albert Haynesworth | GBA | Right Tackle | 3 | 15 |
| Ed Reed | MIA | Free Safety | 3 | 6 |
| Ronald Bartell | SFR | 1st Defensive Back | 2 | 24 |
| Ebenezer Ekuban | HOU | Right End | 2 | 21 |
| Derrick Brooks | SEA | Right LB | 2 | 19 |
| Will A. Allen | SDI | Free Safety | 2 | 19 |
| Mike Rucker | PIT | Right End | 2 | 18 |
| Elvis Dumervil | JAX | Def End | 2 | 18 |
| Patrick Kerney | NYG | Left End | 2 | 17 |
| Adewale Ogunleye | SEA | Left End | 2 | 17 |
| Marcus Stroud | BUF | Left Tackle | 2 | 16 |
| Bryant Young | BUF | Left End | 2 | 16 |
| Darryl Tapp | SFR | Def End | 2 | 16 |
| Dewayne White | SFR | Right End | 2 | 16 |
| Jamal Williams | CIN | Nose Tackle | 2 | 15 |
| Tyrone Poole | SFR | 1st Defensive Back | 2 | 15 |
| Ben Leber | IND | Left LB | 2 | 14 |
| Tank Johnson | NEN | Right Tackle | 2 | 14 |
| Hollis Thomas | BAL | Right Tackle | 2 | 14 |
| Troy Polamalu | DEN | Strong Safety | 2 | 13 |
| Antonio Pierce | JAX | Middle LB | 2 | 12 |
| Keith Lewis | OAK | Free Safety | 2 | 12 |
| Stephen Cooper | HOU | I LB | 2 | 11 |
| Roy Williams | BUF | Strong Safety | 2 | 10 |
| Fred Robbins | MIN | Right Tackle | 2 | 10 |
| Chris Hovan | PIT | Left Tackle | 2 | 10 |
| Brady Poppinga | BAL | Left LB | 2 | 10 |
| Michael Boley | JAX | Left LB | 2 | 10 |
| Randall Godfrey | ARI | Left I LB | 2 | 10 |
| D'Qwell Jackson | SDI | Right I LB | 2 | 9 |
| LeRoy Hill | SFR | Left LB | 2 | 9 |
| Demorrio Williams | OAK | LB | 2 | 8 |
| Derrick Johnson | NYJ | Left LB | 2 | 4 |
| Grady Jackson | PIT | Left Tackle | 2 | 2 |
| Nick Barnett | NYJ | Middle LB | 2 | 1 |
| Jason Ferguson | ARI | Nose Tackle | 2 | 0 |
| Fakhir Brown | IND | Right CB | 1 | 12 |
| Rob Meier | MIA | Def Tackle | 1 | 11 |
| Kevin Kaesviharn | DEN | 1st Defensive Back | 1 | 11 |
| Raheem Brock | NYJ | Right Tackle | 1 | 11 |
| Marcus R. Spears | PHI | Left End | 1 | 11 |
| Leon Williams | JAX | I LB | 1 | 10 |
| Fabian Washington | MIA | Right CB | 1 | 10 |
| Brad Kassell | DAL | I LB | 1 | 9 |
| Ray Edwards | SDI | Def End | 1 | 9 |
| Deshea Townsend | SEA | Left CB | 1 | 9 |
| Tully Banta-Cain | PHI | O LB | 1 | 9 |
| Marcus Washington | MIA | Left LB | 1 | 8 |
| Tamba Hali | SDI | Left End | 1 | 8 |
| James Harrison | DAL | O LB | 1 | 8 |
| Anthony Weaver | NEN | Left End | 1 | 7 |
| Chauncey Davis | DET | Def End | 1 | 7 |
| Patrick Surtain | MIA | Right CB | 1 | 7 |
| Landon Johnson | SFR | Right LB | 1 | 7 |
| Larry Foote | CIN | Right I LB | 1 | 7 |
| Paul Spicer | MIA | Right End | 1 | 7 |
| Marlon McCree | DAL | Free Safety | 1 | 7 |
| Roderick Coleman | BUF | Right Tackle | 1 | 7 |
| Daniel Bullocks | JAX | 1st Defensive Back | 1 | 7 |
| Pisa Tinoisamoa | NEN | Right LB | 1 | 7 |
| Deon Grant | BAL | Free Safety | 1 | 7 |
| Barry Cofield | DET | Left Tackle | 1 | 6 |
| Travis LaBoy | NEN | Right End | 1 | 6 |
| Cato June | SDI | Right LB | 1 | 6 |
| Scott Shanle | MIN | Right LB | 1 | 5 |
| Takeo Spikes | CLE | Right LB | 1 | 5 |
| Lance Briggs | IND | Right LB | 1 | 5 |
| Ahmad Brooks | SDI | LB | 1 | 5 |
| Dawan Landry | SEA | Strong Safety | 1 | 5 |
| James Anderson | NYJ | LB | 1 | 5 |
| Nnamdi Asomugha | SFR | Left CB | 1 | 4 |
| Nate Webster | PHI | LB | 1 | 4 |
| Chris Hoke | MIN | Nose Tackle | 1 | 4 |
| Igor Olshansky | CLE | Right End | 1 | 4 |
| Mike Vrabel | GBA | Right O LB | 1 | 4 |
| Brian Urlacher | SEA | Middle LB | 1 | 4 |
| Kelly Herndon | SDI | Left CB | 1 | 3 |
| Mark Simoneau | IND | Middle LB | 1 | 2 |
| Lawyer Milloy | PIT | Strong Safety | 1 | 2 |
| Jeremiah Trotter | DET | Middle LB | 1 | 2 |
| Abdul Hodge | SFR | LB | 1 | 0 |
| Kawika Mitchell | CHI | Middle LB | 1 | 0 |
| Will Witherspoon | NYG | Middle LB | 1 | 0 |
| Barrett Ruud | BAL | Middle LB | 1 | 0 |
| Lofa Tatupu | CLE | Middle LB | 1 | 0 |
| John Thornton | GBA | Right Tackle | 1 | 0 |
| Sum | --- | --- | 533 | 3409 |
| Avg | --- | --- | 3 | 21 |