Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| Adrian L. Peterson | BUF | 359 | 2211 | 6.2 | 73 | 19 | 90 | 3 | 4 | 10 | 4 |
| Frank Gore | ATL | 420 | 2040 | 4.9 | 48 | 12 | 104 | 0 | 2 | 3 | 2 |
| Fred Taylor | SFR | 314 | 1936 | 6.2 | 62 | 10 | 77 | 0 | 0 | 3 | 2 |
| LaDainian Tomlinson | HOU | 371 | 1842 | 5.0 | 37 | 9 | 97 | 7 | 8 | 1 | 1 |
| Brian Westbrook | SDI | 396 | 1831 | 4.6 | 36 | 5 | 85 | 2 | 5 | 7 | 4 |
| Steven Jackson | JAX | 341 | 1817 | 5.3 | 54 | 12 | 68 | 5 | 7 | 6 | 3 |
| Brandon Jacobs | NYG | 265 | 1568 | 5.9 | 20 | 8 | 80 | 3 | 3 | 9 | 3 |
| Ryan Grant | MIN | 285 | 1496 | 5.2 | 66 | 10 | 60 | 0 | 0 | 3 | 2 |
| Jamal Lewis | KCI | 323 | 1496 | 4.6 | 66 | 10 | 69 | 2 | 3 | 7 | 3 |
| Clinton Portis | TBA | 341 | 1388 | 4.1 | 32 | 13 | 78 | 3 | 7 | 7 | 4 |
| Justin Fargas | PHI | 297 | 1378 | 4.6 | 48 | 7 | 77 | 3 | 5 | 1 | 0 |
| LenDale White | NYJ | 353 | 1363 | 3.9 | 27 | 3 | 73 | 3 | 5 | 6 | 3 |
| Selvin Young | SEA | 234 | 1293 | 5.5 | 50 | 4 | 58 | 1 | 1 | 9 | 5 |
| Willie Parker | PIT | 298 | 1253 | 4.2 | 32 | 9 | 64 | 4 | 7 | 1 | 1 |
| Thomas Jones | DET | 295 | 1175 | 4.0 | 36 | 10 | 63 | 1 | 1 | 2 | 1 |
| Marion Barber III | STL | 269 | 1164 | 4.3 | 54 | 5 | 47 | 2 | 2 | 1 | 1 |
| Chester Taylor | OAK | 171 | 1084 | 6.3 | 84 | 8 | 50 | 0 | 0 | 9 | 6 |
| Ronnie Brown | TEN | 223 | 1060 | 4.8 | 45 | 11 | 60 | 4 | 7 | 5 | 3 |
| Maurice Jones-Drew | NEE | 204 | 973 | 4.8 | 52 | 7 | 51 | 1 | 1 | 4 | 1 |
| Cedric Benson | CHI | 255 | 968 | 3.8 | 43 | 1 | 39 | 0 | 0 | 4 | 1 |
| Jerious Norwood | SEA | 192 | 896 | 4.7 | 59 | 2 | 35 | 0 | 0 | 0 | 0 |
| Laurence Maroney | OAK | 189 | 889 | 4.7 | 68 | 4 | 38 | 0 | 2 | 3 | 2 |
| Willis McGahee | BAL | 227 | 883 | 3.9 | 43 | 5 | 50 | 4 | 4 | 2 | 1 |
| Edgerrin James | STL | 221 | 839 | 3.8 | 27 | 12 | 57 | 2 | 2 | 1 | 1 |
| Joseph Addai | MIN | 175 | 811 | 4.6 | 23 | 7 | 42 | 1 | 2 | 0 | 0 |
| Derrick Ward | GBA | 160 | 794 | 5.0 | 25 | 9 | 46 | 0 | 0 | 0 | 0 |
| Michael Turner | NOR | 203 | 747 | 3.7 | 22 | 1 | 34 | 1 | 2 | 2 | 0 |
| DeAngelo Williams | GBA | 140 | 728 | 5.2 | 47 | 4 | 29 | 0 | 0 | 1 | 0 |
| Jesse Chatman | NOR | 153 | 689 | 4.5 | 23 | 6 | 39 | 1 | 1 | 3 | 2 |
| Fred Jackson | DAL | 149 | 686 | 4.6 | 21 | 1 | 24 | 0 | 0 | 0 | 0 |
| Pierre Thomas | DAL | 142 | 552 | 3.9 | 17 | 10 | 26 | 0 | 0 | 1 | 0 |
| Kenny Watson | NEE | 91 | 470 | 5.2 | 24 | 1 | 16 | 0 | 0 | 1 | 0 |
| Kevin Jones | DAL | 95 | 451 | 4.7 | 22 | 3 | 31 | 0 | 0 | 0 | 0 |
| Reggie Bush | GBA | 98 | 437 | 4.5 | 18 | 0 | 19 | 0 | 0 | 8 | 3 |
| Brian Leonard | BAL | 93 | 410 | 4.4 | 27 | 4 | 23 | 1 | 1 | 0 | 0 |
| Najeh Davenport | PIT | 72 | 396 | 5.5 | 39 | 1 | 20 | 1 | 1 | 2 | 1 |
| Ron Dayne | TEN | 109 | 388 | 3.6 | 25 | 0 | 17 | 1 | 2 | 0 | 0 |
| Kenton Keith | NYG | 102 | 373 | 3.7 | 19 | 1 | 16 | 0 | 0 | 1 | 0 |
| Earnest Graham | DET | 79 | 366 | 4.6 | 25 | 3 | 20 | 0 | 0 | 2 | 1 |
| Sammy Morris | BAL | 72 | 340 | 4.7 | 27 | 1 | 13 | 0 | 1 | 3 | 2 |
| David Garrard | DET | 71 | 315 | 4.4 | 19 | 2 | 12 | 0 | 2 | 6 | 1 |
| LaMont Jordan | TBA | 74 | 299 | 4.0 | 31 | 6 | 31 | 5 | 6 | 1 | 1 |
| Kevin Faulk | TBA | 72 | 277 | 3.8 | 13 | 2 | 11 | 0 | 0 | 1 | 1 |
| Ladell Betts | SFR | 63 | 266 | 4.2 | 20 | 5 | 27 | 0 | 0 | 0 | 0 |
| Jason Wright | GBA | 69 | 261 | 3.8 | 18 | 0 | 23 | 2 | 3 | 1 | 1 |
| Jerome Harrison | CHI | 58 | 251 | 4.3 | 15 | 0 | 11 | 0 | 0 | 1 | 1 |
| Correll Buckhalter | SFR | 52 | 212 | 4.1 | 20 | 0 | 12 | 0 | 0 | 0 | 0 |
| DeShaun Foster | NYJ | 34 | 169 | 5.0 | 20 | 3 | 12 | 2 | 2 | 0 | 0 |
| Luke McCown | MIN | 51 | 163 | 3.2 | 13 | 3 | 19 | 5 | 9 | 11 | 5 |
| J.P. Losman | CHI | 39 | 142 | 3.6 | 17 | 1 | 11 | 4 | 6 | 11 | 8 |
| Maurice Morris | HOU | 38 | 141 | 3.7 | 29 | 3 | 9 | 0 | 0 | 0 | 0 |
| Marshawn Lynch | ATL | 39 | 135 | 3.5 | 21 | 1 | 6 | 0 | 0 | 0 | 0 |
| Donovan McNabb | DAL | 68 | 130 | 1.9 | 40 | 1 | 15 | 1 | 1 | 6 | 4 |
| Ben Roethlisberger | JAX | 50 | 127 | 2.5 | 30 | 1 | 9 | 2 | 2 | 12 | 5 |
| Jeff Garcia | NYJ | 38 | 120 | 3.2 | 14 | 0 | 6 | 2 | 2 | 3 | 1 |
| Travis Henry | NEE | 37 | 116 | 3.1 | 18 | 7 | 17 | 2 | 2 | 2 | 1 |
| Jake Delhomme | PIT | 40 | 108 | 2.7 | 13 | 0 | 8 | 2 | 2 | 1 | 1 |
| Jeremi Johnson | DAL | 28 | 98 | 3.5 | 12 | 3 | 11 | 0 | 0 | 0 | 0 |
| Tom Brady | PHI | 30 | 96 | 3.2 | 19 | 0 | 5 | 0 | 0 | 2 | 1 |
| DeDe Dorsey | BUF | 12 | 92 | 7.7 | 17 | 0 | 4 | 0 | 0 | 0 | 0 |
| Thomas Tapeh | SDI | 38 | 87 | 2.3 | 11 | 5 | 12 | 2 | 2 | 0 | 0 |
| Mack Strong | SEA | 26 | 82 | 3.2 | 9 | 2 | 13 | 1 | 1 | 2 | 0 |
| Larry Johnson | SFR | 28 | 82 | 2.9 | 20 | 7 | 14 | 4 | 5 | 0 | 0 |
| Shaun Alexander | BUF | 32 | 82 | 2.6 | 10 | 11 | 18 | 2 | 2 | 0 | 0 |
| Ahman Green | SEA | 27 | 78 | 2.9 | 18 | 2 | 4 | 0 | 0 | 0 | 0 |
| Vince Young | NYJ | 12 | 77 | 6.4 | 19 | 0 | 3 | 0 | 0 | 0 | 0 |
| Brandon Jackson | TEN | 19 | 73 | 3.8 | 16 | 1 | 4 | 0 | 0 | 0 | 0 |
| Reuben Droughns | GBA | 34 | 70 | 2.1 | 8 | 2 | 4 | 0 | 0 | 0 | 0 |
| Matt Hasselbeck | NEE | 36 | 68 | 1.9 | 11 | 2 | 6 | 3 | 4 | 6 | 3 |
| Musa Smith | NYG | 16 | 53 | 3.3 | 8 | 2 | 4 | 0 | 0 | 0 | 0 |
| Julius Jones | PHI | 33 | 52 | 1.6 | 20 | 3 | 6 | 0 | 0 | 0 | 0 |
| Ahmad Bradshaw | CHI | 13 | 51 | 3.9 | 12 | 0 | 1 | 0 | 0 | 3 | 1 |
| Andre Hall | HOU | 10 | 46 | 4.6 | 16 | 0 | 3 | 0 | 1 | 1 | 0 |
| Matt Schaub | STL | 38 | 46 | 1.2 | 9 | 1 | 2 | 0 | 0 | 12 | 7 |
| Jay Cutler | BUF | 22 | 45 | 2.0 | 31 | 0 | 1 | 0 | 1 | 8 | 3 |
| Sage Rosenfels | TEN | 13 | 41 | 3.2 | 14 | 1 | 4 | 1 | 1 | 1 | 1 |
| Drew Brees | HOU | 36 | 41 | 1.1 | 9 | 4 | 6 | 1 | 1 | 8 | 4 |
| Greg Jones | KCI | 23 | 40 | 1.7 | 11 | 3 | 10 | 1 | 6 | 2 | 2 |
| Adrian Peterson | BUF | 11 | 36 | 3.3 | 7 | 2 | 5 | 0 | 0 | 1 | 1 |
| Tony Romo | TBA | 23 | 33 | 1.4 | 15 | 1 | 2 | 0 | 0 | 4 | 2 |
| Joey Harrington | KCI | 15 | 31 | 2.1 | 7 | 1 | 1 | 0 | 0 | 2 | 0 |
| Derek Anderson | SEA | 25 | 28 | 1.1 | 11 | 2 | 9 | 3 | 5 | 3 | 0 |
| Michael Robinson | JAX | 8 | 27 | 3.4 | 13 | 1 | 2 | 0 | 0 | 0 | 0 |
| Jon Kitna | OAK | 36 | 26 | 0.7 | 9 | 3 | 6 | 1 | 1 | 19 | 11 |
| Marcel Shipp | SEA | 4 | 23 | 5.8 | 14 | 1 | 2 | 0 | 0 | 0 | 0 |
| Eli Manning | TEN | 14 | 21 | 1.5 | 13 | 0 | 3 | 0 | 2 | 4 | 3 |
| Rudi Johnson | DAL | 6 | 18 | 3.0 | 5 | 0 | 3 | 0 | 0 | 0 | 0 |
| Chris B. Brown | ATL | 4 | 15 | 3.8 | 8 | 0 | 1 | 0 | 0 | 0 | 0 |
| Garrett Wolfe | JAX | 6 | 14 | 2.3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Priest Holmes | OAK | 4 | 12 | 3.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brad Hoover | SFR | 11 | 12 | 1.1 | 5 | 2 | 2 | 0 | 0 | 1 | 1 |
| Antonio Pittman | STL | 6 | 11 | 1.8 | 4 | 2 | 4 | 0 | 1 | 0 | 0 |
| Cecil Sapp | CHI | 8 | 10 | 1.3 | 6 | 1 | 3 | 0 | 0 | 1 | 1 |
| Shane Lechler | NOR | 1 | 9 | 9.0 | 9 | 0 | 1 | 0 | 0 | 0 | 0 |
| Carey Davis | JAX | 1 | 7 | 7.0 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
| Ovie Mughelli | NOR | 1 | 5 | 5.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mike Sellers | PIT | 2 | 5 | 2.5 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| Justin Griffith | NEE | 4 | 5 | 1.3 | 3 | 2 | 2 | 0 | 0 | 1 | 0 |
| Tony Richardson | MIN | 4 | 5 | 1.3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 |
| Chris Redman | BAL | 6 | 5 | 0.8 | 3 | 0 | 0 | 0 | 0 | 3 | 1 |
| Kerry Collins | SDI | 11 | 5 | 0.5 | 5 | 1 | 1 | 0 | 0 | 5 | 1 |
| Darius Walker | KCI | 1 | 4 | 4.0 | 4 | 0 | 1 | 0 | 0 | 0 | 0 |
| Oliver Hoyte | BUF | 2 | 1 | 0.5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Warrick Dunn | NEE | 2 | 1 | 0.5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Marc Bulger | SEA | 5 | 0 | 0.0 | 1 | 1 | 1 | 0 | 0 | 2 | 0 |
| Daniel Sepulveda | SEA | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Heath Evans | ATL | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Santonio Holmes | PIT | 5 | -1 | -0.2 | 12 | 0 | 0 | 0 | 0 | 4 | 3 |
| Matt Leinart | KCI | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Damon Huard | ATL | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dan Kreider | STL | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kyle Eckel | DET | 3 | -2 | -0.7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cleo Lemon | SFR | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Alex D. Smith | OAK | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Torry Holt | KCI | 3 | -3 | -1.0 | 8 | 0 | 0 | 0 | 0 | 1 | 0 |
| Greg Camarillo | DAL | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kurt Warner | NYG | 19 | -4 | -0.2 | 1 | 1 | 1 | 0 | 0 | 14 | 6 |
| Sam Hurd | MIN | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Reggie Brown | MIN | 1 | -5 | -5.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Kevin Walter | SEA | 1 | -5 | -5.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Peyton Manning | ATL | 9 | -6 | -0.7 | 0 | 0 | 0 | 0 | 1 | 3 | 2 |
| Donte' Stallworth | DAL | 2 | -6 | -3.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Roy E. Williams | GBA | 1 | -7 | -7.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brett Favre | GBA | 18 | -8 | -0.4 | 1 | 3 | 3 | 0 | 0 | 4 | 2 |
| Devery Henderson | SDI | 2 | -9 | -4.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Shaun Hill | NOR | 23 | -10 | -0.4 | 0 | 0 | 0 | 0 | 0 | 17 | 9 |
| Carson Palmer | SFR | 16 | -10 | -0.6 | 4 | 0 | 0 | 0 | 0 | 4 | 2 |
| Chad Pennington | NYG | 15 | -15 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sum | --- | 10545 | 46377 | --- | 2417 | 357 | 2415 | 102 | 157 | 325 | 162 |
| Avg | --- | 82 | 362 | --- | 19 | 3 | 19 | 1 | 1 | 3 | 1 |