Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Trent Cole | HOU | Right End | 15 | 110 |
| Patrick Kerney | PIT | Left End | 15 | 106 |
| Osi Umenyiora | TBA | Right End | 12 | 94 |
| Adewale Ogunleye | TBA | Left End | 12 | 90 |
| DeMarcus Ware | BUF | Right O LB | 11 | 73 |
| James Harrison | BUF | Right O LB | 11 | 67 |
| Jared Allen | BUF | Right End | 10 | 71 |
| Jovan Haye | HOU | Right Tackle | 10 | 61 |
| Aaron Schobel | SFR | Right End | 9 | 62 |
| Tommie Harris | TBA | Left Tackle | 9 | 61 |
| Mike Vrabel | DET | Left O LB | 9 | 59 |
| Justin Tuck | STL | Def End | 9 | 58 |
| Shawne Merriman | BAL | Left O LB | 9 | 57 |
| Mario Williams | SDI | Right End | 9 | 56 |
| Greg Ellis | STL | Left O LB | 9 | 54 |
| Brian Robison | SEA | Def End | 8 | 58 |
| Bryant Young | OAK | Left End | 8 | 56 |
| Ray Edwards | NYG | Right End | 8 | 53 |
| Dewayne White | STL | Right End | 8 | 49 |
| Paul Spicer | KCI | Right End | 7 | 50 |
| Terrell Suggs | SDI | Right O LB | 7 | 44 |
| Shaun Rogers | TEN | Right Tackle | 7 | 33 |
| Will Witherspoon | DAL | Middle LB | 7 | 31 |
| Adam Carriker | DET | Right Tackle | 7 | 31 |
| Mike Patterson | HOU | Left Tackle | 6 | 48 |
| Derrick Burgess | JAX | Right End | 6 | 47 |
| Lance Briggs | TBA | Right LB | 6 | 46 |
| Shaun Ellis | MIN | Left End | 6 | 44 |
| Corey Williams | DAL | Right Tackle | 6 | 44 |
| Tamba Hali | ATL | Left End | 6 | 43 |
| Aaron Kampman | DAL | Left End | 6 | 42 |
| Will Smith | TEN | Right End | 6 | 38 |
| Darnell Dockett | ATL | Left Tackle | 6 | 32 |
| Thomas Howard | STL | Left LB | 6 | 21 |
| Nick Barnett | STL | Middle LB | 5 | 42 |
| LaMarr Woodley | DAL | O LB | 5 | 41 |
| Fred Robbins | JAX | Right Tackle | 5 | 41 |
| Joey Porter | MIN | Left LB | 5 | 39 |
| Ty Warren | TEN | Left End | 5 | 36 |
| Antwan Odom | NYJ | Left End | 5 | 34 |
| Kyle Vanden Bosch | NEE | Right End | 5 | 33 |
| Elvis Dumervil | PIT | Right End | 5 | 33 |
| John Abraham | MIN | Right End | 5 | 30 |
| La'Roi Glover | KCI | Left Tackle | 5 | 30 |
| Bryan Thomas | PIT | Left O LB | 5 | 27 |
| Michael Strahan | JAX | Left End | 5 | 24 |
| Albert Haynesworth | STL | Right Tackle | 5 | 18 |
| Warren Sapp | MIN | Left Tackle | 5 | 14 |
| Gaines Adams | CHI | Right End | 4 | 32 |
| Darryl Tapp | SEA | Right End | 4 | 30 |
| David Harris | TEN | Right I LB | 4 | 30 |
| Reggie Hayward | HOU | Left End | 4 | 29 |
| Shaun Phillips | HOU | Right O LB | 4 | 28 |
| Gerard Warren | SFR | Right Tackle | 4 | 26 |
| Clark Haggans | PIT | Left O LB | 4 | 24 |
| Jason Taylor | DET | Right End | 4 | 22 |
| Kevin Williams | NYG | Right Tackle | 4 | 21 |
| Ryan Pickett | BUF | Left Tackle | 4 | 20 |
| Matt Wilhelm | HOU | Left I LB | 4 | 18 |
| Larry Foote | PIT | Right I LB | 4 | 18 |
| Mark Anderson | DAL | Right End | 4 | 16 |
| Kevin Carter | ATL | Left End | 3 | 30 |
| John Henderson | TEN | Right Tackle | 3 | 27 |
| Bradie James | TBA | Left I LB | 3 | 26 |
| Kyle Williams | PHI | Right Tackle | 3 | 25 |
| Andre Carter | CHI | Right End | 3 | 23 |
| John Lynch | ATL | Free Safety | 3 | 23 |
| Brent Hawkins | PHI | Def End | 3 | 23 |
| Michael Boley | SDI | Left LB | 3 | 21 |
| Brian Urlacher | PIT | Middle LB | 3 | 20 |
| Ed Johnson | BAL | Right Tackle | 3 | 19 |
| Landon Johnson | DAL | Middle LB | 3 | 18 |
| Chris Kelsay | DAL | Left End | 3 | 18 |
| Chris Hovan | JAX | Left Tackle | 3 | 17 |
| Lofa Tatupu | NYJ | Middle LB | 3 | 14 |
| Larry Tripplett | CHI | Left Tackle | 3 | 8 |
| Casey Hampton | PIT | Nose Tackle | 3 | 3 |
| Kelly Jennings | NEE | Right CB | 2 | 18 |
| Julian Peterson | SEA | Right LB | 2 | 17 |
| Troy Polamalu | HOU | Strong Safety | 2 | 17 |
| Marlon McCree | OAK | Free Safety | 2 | 15 |
| Clint Ingram | OAK | Left LB | 2 | 15 |
| Ben Leber | PHI | Left LB | 2 | 15 |
| Marcus Washington | DET | Left LB | 2 | 15 |
| Chris Clemons | BUF | Def End | 2 | 15 |
| Kenechi Udeze | NYJ | Left End | 2 | 14 |
| John Thornton | KCI | Right Tackle | 2 | 14 |
| Marcus Stroud | NYG | Left Tackle | 2 | 14 |
| Cornelius Griffin | ATL | Left Tackle | 2 | 13 |
| Hollis Thomas | MIN | Left Tackle | 2 | 12 |
| Kawika Mitchell | CHI | Right LB | 2 | 12 |
| Pat Williams | HOU | Left Tackle | 2 | 12 |
| Robaire Smith | SFR | Right End | 2 | 12 |
| Willie McGinest | PHI | Left O LB | 2 | 11 |
| Derrick Johnson | NYJ | Left LB | 2 | 11 |
| Dwight Freeney | NYG | Right End | 2 | 11 |
| N.D. Kalu | NEE | Def End | 2 | 10 |
| Napoleon Harris | JAX | Middle LB | 2 | 10 |
| James Sanders | TBA | Free Safety | 2 | 10 |
| Robert Mathis | NOR | Left End | 2 | 9 |
| Jamie Winborn | NEE | LB | 2 | 9 |
| Raheem Brock | BAL | Left Tackle | 2 | 9 |
| Calvin Pace | JAX | Left LB | 2 | 8 |
| DeMeco Ryans | SDI | Middle LB | 2 | 8 |
| Kirk Morrison | SFR | Middle LB | 2 | 8 |
| Darwin Walker | DET | Right Tackle | 2 | 7 |
| Kelly Gregg | SEA | Nose Tackle | 2 | 5 |
| Vince Wilfork | SDI | Nose Tackle | 2 | 4 |
| Junior Seau | NEE | I LB | 2 | 4 |
| Kris Jenkins | SFR | Right Tackle | 2 | 2 |
| Aubrayo Franklin | NEE | Nose Tackle | 2 | 1 |
| Na'il Diggs | DAL | Right LB | 1 | 11 |
| Barrett Ruud | TBA | Middle LB | 1 | 11 |
| Chris McAlister | ATL | Left CB | 1 | 11 |
| Adalius Thomas | BAL | Right I LB | 1 | 11 |
| E.J. Henderson | NYG | Middle LB | 1 | 11 |
| Haloti Ngata | NOR | Right End | 1 | 10 |
| Kelvin Hayden | TBA | Left CB | 1 | 10 |
| Donnie Edwards | GBA | Right LB | 1 | 10 |
| Clinton Hart | DAL | Strong Safety | 1 | 10 |
| Gerald Hayes | CHI | Middle LB | 1 | 9 |
| Sean Jones | SDI | Strong Safety | 1 | 9 |
| Kenyon Coleman | PHI | Right End | 1 | 9 |
| Brett Keisel | BUF | Right End | 1 | 9 |
| Greg White | NOR | Def End | 1 | 9 |
| Justin Smith | GBA | Right End | 1 | 9 |
| Scott Fujita | TEN | Left LB | 1 | 8 |
| Patrick Willis | BUF | Right I LB | 1 | 8 |
| Domata Peko | DAL | Left Tackle | 1 | 8 |
| Kabeer Gbaja-Biamila | OAK | Def End | 1 | 8 |
| Jamar Williams | JAX | LB | 1 | 8 |
| Turk McBride | BAL | Def End | 1 | 8 |
| Ed Reed | NYG | Free Safety | 1 | 8 |
| Rosevelt Colvin | NYG | Right O LB | 1 | 8 |
| Sam Madison | PIT | Right CB | 1 | 8 |
| Barry Cofield | CHI | Left Tackle | 1 | 8 |
| Robert Geathers | SDI | Left End | 1 | 8 |
| Chris Gamble | TEN | Left CB | 1 | 8 |
| Amobi Okoye | STL | Left Tackle | 1 | 7 |
| Marques Douglas | BAL | Right End | 1 | 7 |
| Ernie Sims | HOU | Right LB | 1 | 7 |
| Cory Redding | NOR | Left Tackle | 1 | 7 |
| Chinedum Ndukwe | DAL | 1st Defensive Back | 1 | 7 |
| Chaun Thompson | SEA | O LB | 1 | 7 |
| Jarret Johnson | NOR | Left O LB | 1 | 7 |
| Karlos Dansby | NOR | Right LB | 1 | 7 |
| Angelo Crowell | TBA | Left LB | 1 | 7 |
| Eric Weddle | SFR | 1st Defensive Back | 1 | 6 |
| Eugene Wilson | DET | 1st Defensive Back | 1 | 6 |
| Kerry Rhodes | BAL | Strong Safety | 1 | 6 |
| D'Qwell Jackson | DAL | Right I LB | 1 | 6 |
| James Farrior | GBA | Left I LB | 1 | 6 |
| James Butler | STL | Strong Safety | 1 | 6 |
| Dunta Robinson | BUF | Left CB | 1 | 5 |
| Chris Hoke | PHI | Nose Tackle | 1 | 5 |
| Leroy Hill | SDI | Left LB | 1 | 5 |
| Vonnie Holliday | DET | Right Tackle | 1 | 5 |
| Rob Meier | OAK | Def Tackle | 1 | 5 |
| Ronald Fields | OAK | Def End | 1 | 5 |
| Keith Bulluck | ATL | Right LB | 1 | 4 |
| Andra Davis | PHI | Left I LB | 1 | 4 |
| Ronde Barber | TBA | Left CB | 1 | 4 |
| Reed Doughty | PHI | Strong Safety | 1 | 4 |
| Scott Shanle | ATL | Right LB | 1 | 4 |
| Antoine Bethea | GBA | Free Safety | 1 | 3 |
| Josh Bullocks | MIN | Free Safety | 1 | 3 |
| Deke Cooper | GBA | Free Safety | 1 | 3 |
| Rocky Boiman | BAL | LB | 1 | 3 |
| Akin Ayodele | NOR | Right I LB | 1 | 3 |
| Cullen Jenkins | NOR | Right End | 1 | 2 |
| London Fletcher | ATL | Middle LB | 1 | 1 |
| Ray Lewis | GBA | Left I LB | 1 | 0 |
| Mike Peterson | OAK | Middle LB | 1 | 0 |
| Ryan Fowler | DET | Middle LB | 1 | 0 |
| Mark Simoneau | SEA | Middle LB | 1 | 0 |
| Jim Leonhard | NEE | 1st Defensive Back | 1 | 0 |
| Dwan Edwards | BUF | Left End | 1 | 0 |
| Jamal Williams | GBA | Nose Tackle | 1 | 0 |
| Darren Sharper | NEE | Strong Safety | 1 | 0 |
| Sum | --- | --- | 592 | 3739 |
| Avg | --- | --- | 3 | 21 |