Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| Brandon Jacobs | ARI | 358 | 2284 | 6.4 | 43 | 15 | 118 | 4 | 5 | 9 | 4 |
| Frank Gore | SEA | 417 | 2109 | 5.1 | 43 | 10 | 102 | 4 | 6 | 11 | 6 |
| Fred Taylor | BUF | 348 | 2067 | 5.9 | 79 | 13 | 75 | 0 | 3 | 0 | 0 |
| LaDainian Tomlinson | PHI | 395 | 1966 | 5.0 | 48 | 11 | 78 | 1 | 1 | 6 | 3 |
| Willie Parker | MIA | 385 | 1836 | 4.8 | 32 | 5 | 70 | 2 | 4 | 4 | 2 |
| Jamal Lewis | DET | 356 | 1711 | 4.8 | 66 | 13 | 87 | 7 | 7 | 5 | 4 |
| Adrian L. Peterson | JAX | 348 | 1679 | 4.8 | 73 | 10 | 76 | 2 | 3 | 6 | 2 |
| Brian Westbrook | IND | 311 | 1622 | 5.2 | 36 | 4 | 70 | 2 | 3 | 3 | 0 |
| Ryan Grant | DAL | 292 | 1526 | 5.2 | 62 | 19 | 86 | 2 | 2 | 3 | 3 |
| Marion Barber III | NYJ | 269 | 1494 | 5.6 | 54 | 13 | 65 | 2 | 2 | 2 | 2 |
| Steven Jackson | MIN | 336 | 1470 | 4.4 | 54 | 13 | 62 | 3 | 3 | 10 | 2 |
| Laurence Maroney | SDI | 327 | 1467 | 4.5 | 37 | 3 | 63 | 0 | 0 | 3 | 2 |
| Clinton Portis | NEE | 319 | 1391 | 4.4 | 32 | 5 | 70 | 1 | 3 | 6 | 3 |
| Maurice Jones-Drew | CLE | 259 | 1338 | 5.2 | 57 | 5 | 63 | 0 | 4 | 2 | 2 |
| Ronnie Brown | CIN | 244 | 1223 | 5.0 | 60 | 5 | 58 | 1 | 3 | 3 | 1 |
| Willis McGahee | CAR | 304 | 1214 | 4.0 | 46 | 8 | 55 | 5 | 7 | 1 | 1 |
| Justin Fargas | OAK | 250 | 1143 | 4.6 | 32 | 9 | 64 | 2 | 2 | 3 | 2 |
| Chester Taylor | BAL | 188 | 1074 | 5.7 | 45 | 7 | 55 | 0 | 2 | 7 | 4 |
| Derrick Ward | SFR | 219 | 969 | 4.4 | 44 | 6 | 46 | 6 | 9 | 7 | 5 |
| DeAngelo Williams | NYG | 168 | 832 | 5.0 | 59 | 8 | 36 | 0 | 0 | 1 | 0 |
| Correll Buckhalter | STL | 174 | 819 | 4.7 | 30 | 3 | 43 | 0 | 0 | 6 | 1 |
| Larry Johnson | GBA | 215 | 818 | 3.8 | 54 | 1 | 40 | 2 | 2 | 2 | 1 |
| Ron Dayne | SFR | 188 | 794 | 4.2 | 39 | 6 | 39 | 2 | 4 | 3 | 1 |
| Michael Turner | SDI | 156 | 716 | 4.6 | 59 | 10 | 54 | 6 | 8 | 2 | 2 |
| Thomas Jones | CIN | 176 | 701 | 4.0 | 30 | 5 | 39 | 1 | 1 | 2 | 1 |
| Sammy Morris | HOU | 146 | 656 | 4.5 | 22 | 4 | 42 | 1 | 1 | 0 | 0 |
| Travis Henry | HOU | 156 | 621 | 4.0 | 33 | 2 | 24 | 1 | 1 | 1 | 1 |
| Brian Leonard | STL | 155 | 613 | 4.0 | 18 | 6 | 31 | 0 | 0 | 0 | 0 |
| Earnest Graham | CHI | 186 | 592 | 3.2 | 28 | 6 | 34 | 3 | 5 | 6 | 4 |
| Marshawn Lynch | NYJ | 137 | 564 | 4.1 | 56 | 6 | 31 | 3 | 3 | 1 | 0 |
| Jason Wright | BAL | 143 | 562 | 3.9 | 18 | 7 | 39 | 4 | 4 | 3 | 1 |
| Shaun Alexander | NYG | 148 | 536 | 3.6 | 25 | 3 | 38 | 0 | 2 | 0 | 0 |
| Selvin Young | BUF | 92 | 459 | 5.0 | 20 | 12 | 39 | 3 | 5 | 1 | 0 |
| Jerious Norwood | DAL | 87 | 438 | 5.0 | 67 | 1 | 19 | 0 | 0 | 2 | 1 |
| Dominic Rhodes | GBA | 97 | 386 | 4.0 | 22 | 3 | 21 | 1 | 2 | 0 | 0 |
| Reggie Bush | CHI | 96 | 373 | 3.9 | 22 | 2 | 20 | 0 | 0 | 13 | 5 |
| Kenton Keith | CLE | 104 | 359 | 3.5 | 22 | 3 | 22 | 0 | 0 | 0 | 0 |
| Darius Walker | OAK | 59 | 304 | 5.2 | 19 | 1 | 13 | 0 | 0 | 0 | 0 |
| Cedric Benson | OAK | 97 | 289 | 3.0 | 20 | 5 | 19 | 0 | 0 | 1 | 1 |
| Edgerrin James | DAL | 61 | 276 | 4.5 | 27 | 2 | 15 | 1 | 1 | 1 | 0 |
| Maurice Morris | SFR | 44 | 269 | 6.1 | 46 | 0 | 12 | 0 | 0 | 0 | 0 |
| Michael Robinson | SEA | 47 | 253 | 5.4 | 28 | 5 | 25 | 3 | 3 | 1 | 1 |
| Ben Roethlisberger | OAK | 49 | 247 | 5.0 | 30 | 4 | 14 | 2 | 3 | 6 | 5 |
| DeShawn Wynn | OAK | 54 | 240 | 4.4 | 44 | 0 | 11 | 0 | 0 | 0 | 0 |
| David Garrard | NYJ | 53 | 227 | 4.3 | 19 | 2 | 15 | 0 | 0 | 4 | 4 |
| LenDale White | NEE | 63 | 217 | 3.4 | 27 | 5 | 17 | 2 | 3 | 1 | 1 |
| Cadillac Williams | CHI | 52 | 215 | 4.1 | 17 | 1 | 13 | 0 | 0 | 1 | 0 |
| Jesse Chatman | MIA | 54 | 212 | 3.9 | 23 | 1 | 14 | 2 | 3 | 1 | 0 |
| J.P. Losman | STL | 50 | 148 | 3.0 | 13 | 3 | 11 | 1 | 1 | 15 | 8 |
| Jay Cutler | DET | 33 | 137 | 4.2 | 21 | 0 | 12 | 3 | 4 | 5 | 2 |
| Joseph Addai | IND | 47 | 135 | 2.9 | 18 | 3 | 8 | 0 | 0 | 0 | 0 |
| Jeff Garcia | SDI | 32 | 119 | 3.7 | 14 | 2 | 8 | 3 | 3 | 4 | 2 |
| Luke McCown | PHI | 38 | 112 | 2.9 | 17 | 3 | 18 | 4 | 5 | 6 | 2 |
| Julius Jones | MIN | 48 | 108 | 2.3 | 18 | 4 | 7 | 0 | 0 | 2 | 1 |
| Tom Brady | HOU | 29 | 103 | 3.6 | 12 | 3 | 7 | 2 | 3 | 5 | 4 |
| Brett Favre | MIN | 38 | 86 | 2.3 | 21 | 3 | 15 | 5 | 5 | 6 | 2 |
| DeDe Dorsey | PHI | 17 | 85 | 5.0 | 18 | 0 | 4 | 0 | 0 | 0 | 0 |
| Ahman Green | ARI | 37 | 84 | 2.3 | 15 | 4 | 8 | 0 | 0 | 1 | 1 |
| Jake Delhomme | SFR | 39 | 83 | 2.1 | 10 | 1 | 7 | 1 | 1 | 2 | 2 |
| Pierre Thomas | DET | 31 | 73 | 2.4 | 7 | 2 | 4 | 0 | 0 | 0 | 0 |
| Najeh Davenport | JAX | 26 | 72 | 2.8 | 16 | 2 | 5 | 1 | 1 | 0 | 0 |
| Matt Schaub | SEA | 53 | 63 | 1.2 | 12 | 0 | 11 | 6 | 6 | 9 | 3 |
| Donovan McNabb | BUF | 26 | 62 | 2.4 | 16 | 2 | 5 | 0 | 0 | 4 | 2 |
| Fred Jackson | DAL | 20 | 53 | 2.7 | 20 | 0 | 2 | 0 | 0 | 0 | 0 |
| Ahmad Bradshaw | NYJ | 6 | 52 | 8.7 | 36 | 0 | 1 | 0 | 0 | 1 | 1 |
| Heath Evans | SEA | 20 | 51 | 2.5 | 9 | 10 | 13 | 0 | 1 | 0 | 0 |
| Adrian Peterson | HOU | 7 | 49 | 7.0 | 21 | 0 | 5 | 1 | 2 | 0 | 0 |
| Warrick Dunn | STL | 18 | 48 | 2.7 | 6 | 1 | 3 | 0 | 0 | 0 | 0 |
| Jon Kitna | CIN | 35 | 48 | 1.4 | 11 | 2 | 10 | 2 | 2 | 21 | 12 |
| Vince Young | CHI | 9 | 46 | 5.1 | 19 | 0 | 4 | 1 | 2 | 0 | 0 |
| Kenny Watson | JAX | 17 | 46 | 2.7 | 17 | 2 | 4 | 0 | 1 | 0 | 0 |
| Drew Brees | BAL | 21 | 43 | 2.0 | 6 | 0 | 4 | 1 | 2 | 4 | 1 |
| DeShaun Foster | BAL | 9 | 42 | 4.7 | 15 | 1 | 2 | 0 | 0 | 1 | 0 |
| Tony Romo | CAR | 17 | 41 | 2.4 | 15 | 1 | 4 | 0 | 0 | 6 | 2 |
| Derek Anderson | IND | 18 | 40 | 2.2 | 11 | 2 | 4 | 0 | 1 | 4 | 0 |
| Matt Hasselbeck | JAX | 23 | 40 | 1.7 | 9 | 0 | 2 | 0 | 0 | 8 | 5 |
| Thomas Tapeh | NYJ | 14 | 35 | 2.5 | 6 | 6 | 10 | 2 | 2 | 0 | 0 |
| Kevin Faulk | PHI | 14 | 32 | 2.3 | 12 | 0 | 2 | 0 | 0 | 0 | 0 |
| T.J. Duckett | DET | 18 | 31 | 1.7 | 18 | 1 | 3 | 0 | 0 | 0 | 0 |
| Ladell Betts | CAR | 11 | 26 | 2.4 | 8 | 2 | 2 | 0 | 1 | 0 | 0 |
| Reuben Droughns | SFR | 11 | 25 | 2.3 | 8 | 3 | 5 | 0 | 1 | 0 | 0 |
| Sage Rosenfels | PHI | 11 | 23 | 2.1 | 9 | 0 | 2 | 0 | 0 | 2 | 1 |
| Eli Manning | MIA | 38 | 23 | 0.6 | 8 | 1 | 5 | 0 | 0 | 16 | 8 |
| LaMont Jordan | NEE | 6 | 22 | 3.7 | 18 | 1 | 2 | 0 | 0 | 0 | 0 |
| Andre Hall | ARI | 8 | 20 | 2.5 | 9 | 0 | 2 | 0 | 0 | 0 | 0 |
| Greg Jones | CHI | 13 | 17 | 1.3 | 3 | 2 | 4 | 1 | 1 | 0 | 0 |
| Brian Griese | NYG | 21 | 14 | 0.7 | 8 | 3 | 5 | 2 | 2 | 6 | 2 |
| Jerome Harrison | SEA | 4 | 13 | 3.3 | 15 | 0 | 1 | 0 | 0 | 0 | 0 |
| Mike Karney | BAL | 4 | 13 | 3.3 | 7 | 0 | 3 | 1 | 1 | 0 | 0 |
| Daunte Culpepper | CLE | 6 | 13 | 2.2 | 6 | 0 | 2 | 2 | 2 | 4 | 3 |
| Kolby Smith | SDI | 6 | 12 | 2.0 | 6 | 2 | 3 | 1 | 2 | 1 | 1 |
| Tarvaris Jackson | SEA | 1 | 11 | 11.0 | 11 | 1 | 1 | 0 | 0 | 0 | 0 |
| Rudi Johnson | SDI | 2 | 11 | 5.5 | 10 | 0 | 1 | 0 | 0 | 0 | 0 |
| Jackie Battle | ARI | 9 | 10 | 1.1 | 5 | 1 | 4 | 1 | 1 | 0 | 0 |
| Justin Griffith | MIA | 7 | 9 | 1.3 | 5 | 4 | 6 | 2 | 2 | 1 | 0 |
| Dwayne Wright | CLE | 6 | 8 | 1.3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
| A.J. Feeley | OAK | 1 | 7 | 7.0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mike Anderson | SEA | 4 | 7 | 1.8 | 3 | 2 | 2 | 0 | 0 | 1 | 1 |
| Carey Davis | IND | 7 | 7 | 1.0 | 5 | 0 | 0 | 0 | 0 | 1 | 0 |
| Peyton Manning | NEE | 18 | 7 | 0.4 | 5 | 0 | 4 | 0 | 0 | 6 | 3 |
| Jeremi Johnson | SDI | 1 | 6 | 6.0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brandon Jackson | NYJ | 4 | 6 | 1.5 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Philip Rivers | NYG | 7 | 5 | 0.7 | 3 | 1 | 3 | 2 | 2 | 3 | 3 |
| Jason Campbell | SFR | 7 | 5 | 0.7 | 11 | 0 | 1 | 0 | 0 | 0 | 0 |
| Carson Palmer | GBA | 20 | 5 | 0.3 | 5 | 1 | 5 | 3 | 4 | 1 | 1 |
| Terrelle Smith | CIN | 2 | 4 | 2.0 | 4 | 0 | 1 | 1 | 1 | 0 | 0 |
| Antonio Pittman | PHI | 1 | 3 | 3.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mike S. Bell | MIN | 1 | 3 | 3.0 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| Marc Bulger | SDI | 1 | 3 | 3.0 | 3 | 0 | 1 | 1 | 1 | 0 | 0 |
| Vonta Leach | PHI | 2 | 3 | 1.5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Garrett Wolfe | SDI | 2 | 2 | 1.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chad Pennington | CIN | 4 | 2 | 0.5 | 4 | 0 | 1 | 0 | 0 | 1 | 0 |
| Joey Harrington | DAL | 45 | 2 | 0.0 | 7 | 2 | 2 | 0 | 1 | 1 | 1 |
| Chris Redman | CHI | 8 | 1 | 0.1 | 3 | 1 | 2 | 1 | 1 | 6 | 3 |
| Kurt Warner | ARI | 32 | 1 | 0.0 | 3 | 2 | 3 | 0 | 1 | 10 | 4 |
| Chris Chambers | DET | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Andy Lee | CLE | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Tony Richardson | NYG | 4 | 0 | 0.0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
| Steve McNair | SEA | 2 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
| Leonard Weaver | SEA | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kevin Jones | CHI | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jeff Dugan | DAL | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Casey Fitzsimmons | ARI | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Lawrence Vickers | OAK | 4 | -2 | -0.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kellen Clemens | NYJ | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Terrell Owens | NEE | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lorenzo Neal | MIN | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rex Grossman | IND | 3 | -3 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brooks Bollinger | BUF | 3 | -3 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bobby Engram | SEA | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Reggie Wayne | HOU | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
| Kerry Collins | DAL | 4 | -4 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Dennis Northcutt | CIN | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 7 | 2 |
| Reggie Brown | PHI | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
| Todd Collins | CLE | 38 | -7 | -0.2 | 4 | 1 | 3 | 1 | 1 | 20 | 11 |
| Roddy White | CLE | 3 | -8 | -2.7 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Shaun Hill | JAX | 10 | -10 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sum | --- | 10408 | 45627 | --- | 2565 | 377 | 2423 | 133 | 187 | 350 | 179 |
| Avg | --- | 76 | 333 | --- | 19 | 3 | 18 | 1 | 1 | 3 | 1 |