Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Trent Cole | DAL | Right End | 13 | 103 |
| Jovan Haye | DAL | Right Tackle | 13 | 78 |
| Shawne Merriman | MIN | Left O LB | 10 | 69 |
| Aaron Schobel | IND | Right End | 10 | 67 |
| Jason Taylor | DAL | Right End | 10 | 63 |
| Greg Ellis | JAX | Left O LB | 9 | 74 |
| Justin Tuck | PHI | Def End | 9 | 63 |
| La'Roi Glover | IND | Left Tackle | 9 | 63 |
| Jared Allen | BUF | Right End | 9 | 61 |
| James Harrison | DAL | Right O LB | 9 | 60 |
| Tommie Harris | NYG | Left Tackle | 9 | 57 |
| Calvin Pace | CLE | Left LB | 9 | 56 |
| Dewayne White | SFR | Right End | 9 | 54 |
| Darnell Dockett | CLE | Left Tackle | 9 | 50 |
| Patrick Kerney | NYG | Left End | 9 | 48 |
| Kyle Vanden Bosch | NYJ | Right End | 8 | 67 |
| Mike Vrabel | GBA | Left O LB | 8 | 63 |
| Chris Hovan | CAR | Left Tackle | 8 | 58 |
| Will Smith | PHI | Right End | 8 | 57 |
| Fred Robbins | MIN | Right Tackle | 8 | 47 |
| DeMarcus Ware | DAL | Right O LB | 7 | 58 |
| Michael Strahan | MIN | Left End | 7 | 51 |
| Mario Williams | NYJ | Right End | 7 | 44 |
| Bryant Young | BUF | Left End | 7 | 43 |
| Nick Barnett | NYJ | Middle LB | 7 | 40 |
| Shaun Phillips | NEE | Right O LB | 7 | 35 |
| Greg Spires | STL | Def End | 6 | 50 |
| Aaron Kampman | SEA | Left End | 6 | 45 |
| Elvis Dumervil | JAX | Right End | 6 | 44 |
| Julius Peppers | STL | Left End | 6 | 41 |
| Osi Umenyiora | NYG | Right End | 6 | 38 |
| Michael Boley | JAX | Left LB | 6 | 29 |
| Cornelius Griffin | ARI | Left Tackle | 6 | 23 |
| Joey Porter | CIN | Left LB | 5 | 47 |
| Tony Brown | NEE | Left Tackle | 5 | 39 |
| Greg White | NEE | Def End | 5 | 37 |
| Gaines Adams | CAR | Right End | 5 | 36 |
| John Henderson | MIN | Right Tackle | 5 | 33 |
| Julian Peterson | CIN | Right LB | 5 | 31 |
| D'Qwell Jackson | SDI | Right I LB | 5 | 31 |
| Rocky Bernard | HOU | Right Tackle | 5 | 30 |
| Tamba Hali | SDI | Left End | 5 | 30 |
| Paul Spicer | MIA | Right End | 5 | 28 |
| Kris Jenkins | MIA | Right Tackle | 5 | 26 |
| Cullen Jenkins | SDI | Right End | 4 | 40 |
| Mike Rucker | CAR | Right End | 4 | 36 |
| Jared DeVries | DET | Left End | 4 | 33 |
| Alex Brown | ARI | Def End | 4 | 33 |
| Kabeer Gbaja-Biamila | BUF | Def End | 4 | 31 |
| Clark Haggans | GBA | Left O LB | 4 | 30 |
| Ed Johnson | OAK | Right Tackle | 4 | 29 |
| Leroy Hill | SFR | Left LB | 4 | 28 |
| Andre Carter | JAX | Right End | 4 | 28 |
| Kenechi Udeze | OAK | Left End | 4 | 28 |
| Robert Geathers | OAK | Left End | 4 | 28 |
| Amobi Okoye | STL | Left Tackle | 4 | 26 |
| Stephen Nicholas | SEA | LB | 4 | 26 |
| Justin Smith | BAL | Right End | 4 | 24 |
| Ty Warren | GBA | Left End | 4 | 23 |
| Kevin Carter | GBA | Left End | 4 | 21 |
| Shaun Rogers | OAK | Right Tackle | 4 | 19 |
| Kyle Williams | HOU | Right Tackle | 4 | 14 |
| Patrick Willis | NYG | Right I LB | 4 | 11 |
| Phillip Daniels | HOU | Left End | 3 | 28 |
| Terrell Suggs | OAK | Right O LB | 3 | 27 |
| John Abraham | DET | Right End | 3 | 27 |
| Haloti Ngata | CHI | Right End | 3 | 26 |
| Reggie Hayward | SFR | Left End | 3 | 25 |
| Bart Scott | PHI | Right I LB | 3 | 25 |
| Richard Seymour | MIA | Right End | 3 | 24 |
| Lito Sheppard | NYJ | Left CB | 3 | 24 |
| Warren Sapp | PHI | Left Tackle | 3 | 23 |
| Robaire Smith | MIN | Right End | 3 | 22 |
| Pat Williams | NEE | Left Tackle | 3 | 22 |
| Dunta Robinson | BUF | Left CB | 3 | 21 |
| Landon Johnson | SFR | Middle LB | 3 | 19 |
| Brian Robison | NEE | Def End | 3 | 19 |
| Karlos Dansby | BUF | Right LB | 3 | 19 |
| LaMarr Woodley | STL | O LB | 3 | 19 |
| Reggie Nelson | SDI | Free Safety | 3 | 18 |
| Casey Hampton | SEA | Nose Tackle | 3 | 18 |
| Shaun Ellis | IND | Left End | 3 | 18 |
| Kenyon Coleman | PHI | Right End | 3 | 18 |
| Victor Hobson | MIN | Right O LB | 3 | 17 |
| Eric Barton | OAK | Left I LB | 3 | 17 |
| Kirk Morrison | SFR | Middle LB | 3 | 17 |
| Raheem Brock | NYJ | Left Tackle | 3 | 16 |
| Chris Hoke | JAX | Nose Tackle | 3 | 14 |
| Brian Russell | HOU | Free Safety | 3 | 14 |
| Albert Haynesworth | GBA | Right Tackle | 3 | 10 |
| Clint Ingram | NYG | Left LB | 2 | 19 |
| Ray Edwards | SDI | Right End | 2 | 17 |
| DeMeco Ryans | DAL | Middle LB | 2 | 17 |
| Derrick Burgess | CIN | Right End | 2 | 17 |
| Rocky McIntosh | NYJ | Right LB | 2 | 17 |
| Jamar Williams | SEA | LB | 2 | 15 |
| Quintin Mikell | PHI | 1st Defensive Back | 2 | 15 |
| Derrick Brooks | SEA | Right LB | 2 | 14 |
| Aaron Smith | CIN | Left End | 2 | 14 |
| Hollis Thomas | BAL | Left Tackle | 2 | 14 |
| Ian Gold | CAR | Right LB | 2 | 12 |
| Cato June | SDI | Left LB | 2 | 11 |
| Kelly Gregg | NYJ | Nose Tackle | 2 | 11 |
| Keith Brooking | BUF | Middle LB | 2 | 10 |
| Derrick Johnson | NYJ | Left LB | 2 | 10 |
| Brian Urlacher | SEA | Middle LB | 2 | 9 |
| Thomas Davis | NYG | Left LB | 2 | 8 |
| Nate Webster | PHI | Left LB | 2 | 8 |
| Darryl Tapp | SFR | Right End | 2 | 8 |
| Igor Olshansky | CLE | Left End | 2 | 8 |
| Jay Ratliff | CHI | Nose Tackle | 2 | 8 |
| Antoine Bethea | BAL | Free Safety | 2 | 7 |
| Adam Carriker | STL | Right Tackle | 2 | 6 |
| Grady Jackson | CAR | Def Tackle | 2 | 5 |
| Cory Redding | SDI | Left Tackle | 2 | 5 |
| James Farrior | MIN | Left I LB | 2 | 0 |
| Rashean Mathis | MIN | Left CB | 1 | 12 |
| London Fletcher | CIN | Middle LB | 1 | 11 |
| Will Witherspoon | NYG | Middle LB | 1 | 11 |
| Antwan Barnes | STL | O LB | 1 | 10 |
| Kevin Williams | IND | Right Tackle | 1 | 10 |
| Chris Harris | DAL | Strong Safety | 1 | 10 |
| Calvin Lowry | SFR | 1st Defensive Back | 1 | 10 |
| Cortland Finnegan | SEA | Right CB | 1 | 9 |
| Marcus Washington | MIA | Left LB | 1 | 9 |
| Scott Fujita | HOU | Left LB | 1 | 9 |
| Rob Meier | MIA | Def Tackle | 1 | 9 |
| Donnie Edwards | NEE | Right LB | 1 | 8 |
| Thomas Howard | CLE | Left LB | 1 | 8 |
| Damione Lewis | NEE | Def Tackle | 1 | 8 |
| Anthony Weaver | NEE | Left End | 1 | 8 |
| Luis Castillo | BAL | Right End | 1 | 8 |
| Sheldon Brown | PHI | Right CB | 1 | 8 |
| LaRon Landry | OAK | Strong Safety | 1 | 8 |
| Chris Kelsay | ARI | Left End | 1 | 8 |
| Corey Williams | SEA | Right Tackle | 1 | 7 |
| Adewale Ogunleye | SEA | Left End | 1 | 7 |
| Marcus Stroud | BUF | Left Tackle | 1 | 7 |
| Willie McGinest | BAL | Left O LB | 1 | 7 |
| Ben Leber | IND | Left LB | 1 | 7 |
| Bryan Thomas | DET | Left O LB | 1 | 7 |
| O.J. Atogwe | IND | Free Safety | 1 | 6 |
| Patrick Surtain | MIA | Right CB | 1 | 6 |
| Scott Shanle | MIN | Right LB | 1 | 6 |
| Hannibal Navies | STL | I LB | 1 | 6 |
| Marlin Jackson | DAL | Right CB | 1 | 6 |
| John Lynch | NEE | Free Safety | 1 | 6 |
| Clint Session | SDI | LB | 1 | 6 |
| Darren Sharper | JAX | Strong Safety | 1 | 6 |
| Kawika Mitchell | CHI | Right LB | 1 | 6 |
| Tyjuan Hagler | IND | Left LB | 1 | 5 |
| Frank Walker | NYJ | 1st Defensive Back | 1 | 5 |
| Ray Lewis | CAR | Left I LB | 1 | 5 |
| Lawyer Milloy | CAR | Strong Safety | 1 | 5 |
| Rosevelt Colvin | ARI | Right O LB | 1 | 4 |
| Bradie James | DET | Left I LB | 1 | 4 |
| Mike McKenzie | JAX | Left CB | 1 | 4 |
| Drew Coleman | JAX | 1st Defensive Back | 1 | 4 |
| A.J. Hawk | BUF | Right LB | 1 | 4 |
| Stephen Cooper | HOU | Right I LB | 1 | 3 |
| Daryl Smith | MIA | Right LB | 1 | 3 |
| Sean Jones | SEA | Strong Safety | 1 | 3 |
| Eugene Wilson | PHI | 1st Defensive Back | 1 | 2 |
| Ryan Pickett | GBA | Left Tackle | 1 | 2 |
| Jamal Williams | CIN | Nose Tackle | 1 | 0 |
| Larry Foote | CIN | Right I LB | 1 | 0 |
| Jon Beason | ARI | Middle LB | 1 | 0 |
| Mike Peterson | GBA | Middle LB | 1 | 0 |
| Chris Gocong | GBA | Left LB | 1 | 0 |
| Sum | --- | --- | 587 | 3830 |
| Avg | --- | --- | 3 | 23 |