Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| DeAngelo Williams | GBN | 352 | 2014 | 5.7 | 63 | 10 | 72 | 1 | 1 | 0 | 0 |
| Adrian L. Peterson | BFA | 430 | 1976 | 4.6 | 58 | 7 | 75 | 2 | 2 | 12 | 6 |
| Clinton Portis | TBN | 390 | 1939 | 5.0 | 31 | 16 | 101 | 6 | 8 | 1 | 1 |
| Derrick Ward | SEN | 301 | 1796 | 6.0 | 51 | 15 | 79 | 1 | 2 | 0 | 0 |
| Michael Turner | NON | 384 | 1755 | 4.6 | 67 | 8 | 86 | 2 | 2 | 2 | 1 |
| Brandon Jacobs | NYN | 277 | 1694 | 6.1 | 44 | 13 | 81 | 4 | 7 | 2 | 2 |
| Steven Jackson | JXA | 376 | 1618 | 4.3 | 56 | 13 | 89 | 8 | 14 | 5 | 5 |
| Jonathan Stewart | HOA | 334 | 1616 | 4.8 | 41 | 10 | 79 | 3 | 5 | 0 | 0 |
| Jamal Lewis | KCA | 395 | 1599 | 4.0 | 24 | 5 | 77 | 3 | 5 | 3 | 1 |
| Steve Slaton | NYA | 321 | 1536 | 4.8 | 67 | 11 | 67 | 8 | 10 | 8 | 7 |
| Sammy Morris | BAA | 285 | 1502 | 5.3 | 35 | 15 | 89 | 2 | 3 | 2 | 2 |
| Thomas Jones | DEN | 344 | 1472 | 4.3 | 27 | 7 | 77 | 2 | 2 | 2 | 2 |
| Chris D. Johnson | OAA | 305 | 1422 | 4.7 | 34 | 8 | 62 | 1 | 1 | 2 | 0 |
| Ryan Grant | MNN | 339 | 1382 | 4.1 | 54 | 5 | 53 | 0 | 0 | 3 | 2 |
| Julius Jones | PHN | 315 | 1285 | 4.1 | 33 | 3 | 63 | 3 | 4 | 8 | 2 |
| Frank Gore | ATN | 252 | 1284 | 5.1 | 51 | 7 | 50 | 0 | 0 | 2 | 2 |
| Ronnie Brown | TNA | 238 | 1004 | 4.2 | 62 | 4 | 51 | 5 | 7 | 0 | 0 |
| Kevin Smith | SLN | 211 | 870 | 4.1 | 50 | 1 | 33 | 1 | 2 | 0 | 0 |
| Ray Rice | SDA | 174 | 826 | 4.7 | 35 | 2 | 39 | 0 | 0 | 2 | 1 |
| Pierre Thomas | DAN | 168 | 818 | 4.9 | 43 | 11 | 50 | 3 | 4 | 1 | 1 |
| Willie Parker | PIA | 203 | 801 | 3.9 | 18 | 3 | 34 | 1 | 1 | 0 | 0 |
| Marshawn Lynch | ATN | 193 | 799 | 4.1 | 38 | 4 | 55 | 3 | 5 | 3 | 0 |
| Brian Westbrook | SDA | 190 | 797 | 4.2 | 20 | 7 | 44 | 3 | 3 | 0 | 0 |
| Maurice Jones-Drew | NEA | 190 | 771 | 4.1 | 46 | 3 | 35 | 0 | 0 | 11 | 6 |
| Le'Ron McClain | CHN | 213 | 767 | 3.6 | 31 | 9 | 43 | 1 | 2 | 7 | 6 |
| Fred Taylor | SFN | 161 | 732 | 4.5 | 34 | 9 | 31 | 0 | 0 | 1 | 1 |
| Correll Buckhalter | SFN | 164 | 713 | 4.3 | 25 | 3 | 25 | 0 | 0 | 0 | 0 |
| Peyton Hillis | DAN | 133 | 666 | 5.0 | 19 | 3 | 32 | 1 | 1 | 1 | 1 |
| Larry Johnson | SFN | 102 | 614 | 6.0 | 43 | 2 | 36 | 4 | 4 | 4 | 3 |
| LenDale White | NYA | 101 | 491 | 4.9 | 52 | 6 | 26 | 2 | 3 | 2 | 1 |
| Maurice Morris | HOA | 93 | 466 | 5.0 | 44 | 0 | 19 | 0 | 0 | 1 | 1 |
| Ahmad Bradshaw | CHN | 90 | 454 | 5.0 | 35 | 2 | 20 | 0 | 0 | 5 | 2 |
| Fred Jackson | DAN | 91 | 406 | 4.5 | 32 | 5 | 20 | 0 | 0 | 3 | 2 |
| Willis McGahee | BAA | 98 | 374 | 3.8 | 28 | 7 | 25 | 1 | 2 | 0 | 0 |
| Jerious Norwood | SEN | 95 | 370 | 3.9 | 45 | 4 | 16 | 0 | 0 | 3 | 2 |
| Cedric Benson | CHN | 75 | 354 | 4.7 | 30 | 5 | 20 | 0 | 0 | 0 | 0 |
| Ricky Williams | PIA | 86 | 335 | 3.9 | 28 | 4 | 26 | 3 | 3 | 2 | 1 |
| LaMont Jordan | TBN | 89 | 301 | 3.4 | 17 | 4 | 35 | 5 | 5 | 0 | 0 |
| Matt Forte' | GBN | 89 | 297 | 3.3 | 26 | 8 | 31 | 3 | 4 | 0 | 0 |
| Kevin Faulk | TBN | 55 | 277 | 5.0 | 36 | 2 | 8 | 0 | 0 | 2 | 1 |
| Warrick Dunn | NEA | 85 | 246 | 2.9 | 18 | 7 | 18 | 0 | 0 | 1 | 1 |
| Ryan Moats | SFN | 58 | 228 | 3.9 | 12 | 3 | 26 | 0 | 0 | 1 | 1 |
| Joe Flacco | MNN | 66 | 221 | 3.3 | 38 | 3 | 18 | 7 | 10 | 12 | 5 |
| Antonio Pittman | SLN | 58 | 210 | 3.6 | 18 | 0 | 7 | 1 | 1 | 0 | 0 |
| Rudi Johnson | DAN | 55 | 208 | 3.8 | 18 | 3 | 15 | 0 | 0 | 0 | 0 |
| Reggie Bush | GBN | 38 | 197 | 5.2 | 36 | 1 | 5 | 0 | 0 | 4 | 2 |
| Aaron Rodgers | PIA | 32 | 181 | 5.7 | 21 | 3 | 14 | 0 | 1 | 12 | 3 |
| Joseph Addai | MNN | 43 | 175 | 4.1 | 23 | 0 | 8 | 0 | 0 | 1 | 1 |
| Jamaal Charles | TNA | 46 | 171 | 3.7 | 16 | 0 | 3 | 0 | 0 | 3 | 1 |
| Tashard Choice | NYN | 60 | 170 | 2.8 | 38 | 0 | 9 | 1 | 4 | 0 | 0 |
| David Garrard | DEN | 47 | 169 | 3.6 | 12 | 1 | 14 | 3 | 3 | 5 | 4 |
| Benjarvus Green-Ellis | TNA | 56 | 166 | 3.0 | 15 | 4 | 15 | 1 | 1 | 0 | 0 |
| Darren Sproles | PIA | 27 | 158 | 5.9 | 37 | 0 | 5 | 0 | 0 | 2 | 1 |
| Matt Cassel | OAA | 42 | 154 | 3.7 | 13 | 0 | 10 | 3 | 3 | 3 | 2 |
| Earnest Graham | DEN | 64 | 148 | 2.3 | 15 | 1 | 8 | 0 | 1 | 0 | 0 |
| Justin Fargas | PHN | 65 | 147 | 2.3 | 18 | 2 | 8 | 0 | 0 | 0 | 0 |
| Jason Campbell | GBN | 35 | 144 | 4.1 | 23 | 2 | 10 | 1 | 2 | 1 | 0 |
| Edgerrin James | SLN | 57 | 143 | 2.5 | 15 | 3 | 15 | 0 | 1 | 0 | 0 |
| Jason Snelling | SLN | 46 | 140 | 3.0 | 13 | 5 | 24 | 1 | 3 | 0 | 0 |
| Chester Taylor | OAA | 46 | 139 | 3.0 | 16 | 4 | 13 | 0 | 0 | 0 | 0 |
| Jay Cutler | BFA | 41 | 136 | 3.3 | 12 | 2 | 10 | 0 | 1 | 4 | 1 |
| Jeff Garcia | NYA | 41 | 129 | 3.1 | 20 | 1 | 10 | 3 | 3 | 3 | 2 |
| Montell Owens | SEN | 64 | 126 | 2.0 | 12 | 4 | 31 | 4 | 7 | 0 | 0 |
| Dan Orlovsky | BAA | 27 | 113 | 4.2 | 12 | 0 | 4 | 0 | 0 | 6 | 3 |
| Marion Barber III | SLN | 26 | 109 | 4.2 | 18 | 1 | 7 | 1 | 1 | 0 | 0 |
| Michael Bush | JXA | 26 | 104 | 4.0 | 67 | 1 | 5 | 0 | 0 | 0 | 0 |
| Garrett Wolfe | JXA | 11 | 99 | 9.0 | 36 | 1 | 6 | 0 | 0 | 0 | 0 |
| Derek Anderson | PHN | 37 | 99 | 2.7 | 15 | 1 | 5 | 2 | 3 | 16 | 13 |
| J.J. Arrington | NYN | 26 | 89 | 3.4 | 18 | 2 | 5 | 0 | 0 | 1 | 0 |
| Felix Jones | TNA | 23 | 87 | 3.8 | 17 | 2 | 10 | 0 | 0 | 0 | 0 |
| Ben Roethlisberger | JXA | 50 | 74 | 1.5 | 10 | 1 | 6 | 1 | 1 | 19 | 9 |
| Cadillac Williams | NON | 20 | 72 | 3.6 | 28 | 1 | 3 | 0 | 0 | 0 | 0 |
| Matt Ryan | CHN | 48 | 64 | 1.3 | 17 | 4 | 13 | 4 | 6 | 0 | 0 |
| Seneca Wallace | SEN | 32 | 58 | 1.8 | 10 | 2 | 10 | 3 | 3 | 2 | 0 |
| Philip Rivers | NEA | 30 | 46 | 1.5 | 10 | 0 | 3 | 1 | 1 | 6 | 3 |
| Adrian Peterson | BFA | 22 | 44 | 2.0 | 9 | 9 | 11 | 0 | 1 | 0 | 0 |
| Donovan McNabb | DAN | 40 | 44 | 1.1 | 9 | 1 | 4 | 1 | 1 | 2 | 0 |
| LaDainian Tomlinson | HOA | 23 | 41 | 1.8 | 8 | 3 | 5 | 0 | 2 | 0 | 0 |
| Trent Edwards | SDA | 27 | 41 | 1.5 | 9 | 0 | 4 | 1 | 1 | 10 | 5 |
| Carson Palmer | SFN | 32 | 39 | 1.2 | 10 | 1 | 3 | 0 | 1 | 4 | 1 |
| Brett Favre | NON | 24 | 38 | 1.6 | 13 | 3 | 6 | 1 | 2 | 11 | 7 |
| Leonard Weaver | SDA | 11 | 36 | 3.3 | 8 | 1 | 5 | 1 | 1 | 1 | 0 |
| Tim Hightower | HOA | 17 | 35 | 2.1 | 7 | 3 | 9 | 5 | 5 | 0 | 0 |
| DeShawn Wynn | BFA | 2 | 34 | 17.0 | 19 | 0 | 2 | 0 | 0 | 0 | 0 |
| Dominic Rhodes | KCA | 15 | 28 | 1.9 | 8 | 1 | 2 | 0 | 0 | 0 | 0 |
| Matt Schaub | SLN | 34 | 22 | 0.6 | 10 | 0 | 1 | 0 | 1 | 13 | 9 |
| Jake Delhomme | KCA | 16 | 20 | 1.3 | 8 | 0 | 4 | 1 | 1 | 5 | 2 |
| Michael Pittman | MNN | 7 | 19 | 2.7 | 6 | 0 | 1 | 0 | 0 | 0 | 0 |
| Lousaka Polite | NYN | 12 | 19 | 1.6 | 4 | 8 | 9 | 1 | 1 | 1 | 1 |
| Greg Jones | KCA | 9 | 16 | 1.8 | 8 | 1 | 2 | 1 | 1 | 1 | 1 |
| Jacob Hester | HOA | 6 | 15 | 2.5 | 10 | 0 | 1 | 0 | 0 | 2 | 0 |
| Santonio Holmes | PIA | 2 | 14 | 7.0 | 17 | 0 | 0 | 0 | 0 | 1 | 1 |
| Ladell Betts | SFN | 3 | 14 | 4.7 | 7 | 0 | 0 | 0 | 0 | 1 | 1 |
| Matt Hasselbeck | NEA | 1 | 12 | 12.0 | 12 | 0 | 1 | 0 | 0 | 0 | 0 |
| Mewelde Moore | SDA | 10 | 10 | 1.0 | 5 | 0 | 0 | 0 | 1 | 0 | 0 |
| Peyton Manning | ATN | 19 | 10 | 0.5 | 5 | 0 | 4 | 2 | 2 | 2 | 1 |
| Kyle Eckel | DEN | 1 | 8 | 8.0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kellen Clemens | DAN | 4 | 8 | 2.0 | 9 | 0 | 1 | 0 | 0 | 0 | 0 |
| Selvin Young | SEN | 6 | 8 | 1.3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vince Young | NYA | 2 | 7 | 3.5 | 7 | 0 | 1 | 1 | 1 | 1 | 0 |
| Tony Richardson | MNN | 2 | 7 | 3.5 | 5 | 1 | 2 | 0 | 0 | 0 | 0 |
| Ahman Green | SEN | 3 | 7 | 2.3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| T.J. Duckett | BAA | 4 | 6 | 1.5 | 4 | 0 | 0 | 0 | 2 | 0 | 0 |
| Darren McFadden | BFA | 1 | 4 | 4.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Eli Manning | TNA | 15 | 4 | 0.3 | 4 | 1 | 5 | 2 | 2 | 4 | 1 |
| Mike Sellers | PIA | 1 | 3 | 3.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Josh Cribbs | JXA | 1 | 2 | 2.0 | 2 | 0 | 0 | 0 | 0 | 4 | 3 |
| Ahmard Hall | TNA | 1 | 1 | 1.0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Deuce McAllister | DEN | 3 | 1 | 0.3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Moran Norris | NEA | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ovie Mughelli | NON | 2 | 0 | 0.0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Mike Cox | PIA | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Devery Henderson | SDA | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jon Kitna | BFA | 2 | -1 | -0.5 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
| Patrick Ramsey | DEN | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Brodie Croyle | SLN | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lorenzo Neal | GBN | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brandon Lloyd | DAN | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Drew Brees | HOA | 20 | -2 | -0.1 | 5 | 2 | 4 | 1 | 3 | 3 | 3 |
| Chad Pennington | NYN | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Damon Huard | ATN | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Roddy White | TBN | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rob Bironas | DAN | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Sage Rosenfels | TNA | 3 | -3 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Trent Green | PIA | 3 | -3 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kenny Watson | NEA | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Lance Moore | CHN | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Tony Romo | TBN | 22 | -5 | -0.2 | 4 | 1 | 1 | 0 | 0 | 9 | 6 |
| Kurt Warner | NYN | 17 | -6 | -0.4 | 3 | 0 | 0 | 0 | 0 | 7 | 4 |
| Marques Colston | KCA | 1 | -7 | -7.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sum | --- | 10691 | 45684 | --- | 2559 | 364 | 2418 | 137 | 199 | 287 | 162 |
| Avg | --- | 82 | 351 | --- | 20 | 3 | 19 | 1 | 2 | 2 | 1 |