Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Aaron Kampman | DAN | Left End | 14 | 115 |
| DeMarcus Ware | BFA | Right O LB | 11 | 83 |
| Gaines Adams | CHN | Right End | 10 | 79 |
| Ebenezer Ekuban | JXA | Left End | 10 | 61 |
| Justin Tuck | SLN | Left End | 9 | 80 |
| Shaun Phillips | HOA | Left O LB | 9 | 69 |
| James Hall | TBN | Def End | 9 | 59 |
| James Harrison | BFA | Right O LB | 9 | 57 |
| Richard Seymour | NON | Right End | 8 | 60 |
| Jay Ratliff | TBN | Nose Tackle | 8 | 60 |
| Dewayne White | SLN | Right End | 8 | 58 |
| Greg Ellis | SLN | Left O LB | 8 | 55 |
| Mario Williams | SDA | Right End | 8 | 53 |
| Matt Roth | NYA | Left O LB | 7 | 58 |
| Tommie Harris | SEN | Left Tackle | 7 | 56 |
| Adewale Ogunleye | TBN | Left End | 7 | 47 |
| Aaron Smith | PIA | Left End | 7 | 44 |
| Kyle Vanden Bosch | NEA | Right End | 7 | 39 |
| Bradie James | TBN | Left I LB | 7 | 37 |
| LaMarr Woodley | DAN | Left O LB | 6 | 51 |
| Shaun Ellis | MNN | Left End | 6 | 50 |
| John Abraham | MNN | Right End | 6 | 49 |
| Kevin Carter | ATN | Left End | 6 | 48 |
| Terrell Suggs | SDA | Right O LB | 6 | 42 |
| Joey Porter | MNN | Right O LB | 6 | 39 |
| Rocky Bernard | BAA | Right Tackle | 6 | 36 |
| Craig Terrill | OAA | Def Tackle | 6 | 35 |
| Mike Wright | PHN | Def End | 6 | 33 |
| Leonard Little | CHN | Def End | 6 | 32 |
| Tommy Kelly | DAN | Right Tackle | 6 | 30 |
| Shaun Rogers | TNA | Nose Tackle | 6 | 25 |
| Darnell Dockett | ATN | Right Tackle | 6 | 12 |
| Julius Peppers | HOA | Right End | 5 | 45 |
| Jared Allen | BFA | Right End | 5 | 34 |
| Albert Haynesworth | SLN | Right Tackle | 5 | 33 |
| Raheem Brock | BAA | Left End | 5 | 32 |
| Kevin Williams | NYN | Right Tackle | 5 | 30 |
| Sedrick Ellis | BAA | Right Tackle | 5 | 24 |
| Barrett Ruud | TBN | Middle LB | 5 | 17 |
| Ernie Sims | HOA | Right LB | 4 | 34 |
| Ray Edwards | NYN | Left End | 4 | 32 |
| Robert Mathis | NON | Def End | 4 | 31 |
| Kris Jenkins | SFN | Nose Tackle | 4 | 29 |
| Lance Briggs | TBN | Right LB | 4 | 25 |
| D'Qwell Jackson | DAN | Right I LB | 4 | 24 |
| Grady Jackson | BFA | Left Tackle | 4 | 23 |
| Fred Robbins | JXA | Right Tackle | 4 | 20 |
| Cato June | NON | Left LB | 4 | 15 |
| Darren Howard | SDA | Def End | 3 | 32 |
| Dwight Freeney | NYN | Right End | 3 | 24 |
| Karlos Dansby | NON | Right LB | 3 | 24 |
| Andre Carter | CHN | Right End | 3 | 23 |
| Trent Cole | HOA | Right End | 3 | 22 |
| Bertrand Berry | TNA | Def End | 3 | 21 |
| Jason Jones | DEN | Def End | 3 | 21 |
| Reggie Nelson | SLN | Free Safety | 3 | 20 |
| Thomas Howard | SLN | Left LB | 3 | 20 |
| Trevor Scott | SFN | Def End | 3 | 19 |
| Vonnie Holliday | DEN | Right End | 3 | 18 |
| Pat Williams | HOA | Left Tackle | 3 | 17 |
| Brandon Meriweather | PIA | Strong Safety | 3 | 16 |
| Tedy Bruschi | NYN | Right I LB | 3 | 13 |
| Jonathan Babineaux | SLN | Right Tackle | 3 | 11 |
| Nick Barnett | SLN | Middle LB | 3 | 9 |
| Pat Sims | OAA | Def Tackle | 3 | 9 |
| Marcus Stroud | NYN | Left Tackle | 3 | 4 |
| Larry Foote | PIA | Right I LB | 3 | 3 |
| Omar Gaither | MNN | LB | 2 | 20 |
| Derrick Burgess | JXA | Right End | 2 | 18 |
| Charles Grant | SFN | Left End | 2 | 18 |
| Leroy Hill | SDA | Left LB | 2 | 17 |
| Greg White | NON | Def End | 2 | 17 |
| Darryl Tapp | SEN | Left End | 2 | 17 |
| Kedric Golston | DAN | Right Tackle | 2 | 17 |
| Justin Smith | GBN | Right End | 2 | 17 |
| Kerry Rhodes | BAA | Free Safety | 2 | 16 |
| Jevon Kearse | SEN | Left End | 2 | 15 |
| Kalimba Edwards | NYA | Left End | 2 | 15 |
| Mike Peterson | OAA | Middle LB | 2 | 14 |
| Tyler Brayton | PIA | Left End | 2 | 13 |
| Juqua Parker | GBN | Left End | 2 | 13 |
| Stanford Routt | TBN | 1st Defensive Back | 2 | 13 |
| Clint Ingram | OAA | Left LB | 2 | 13 |
| Paul Posluszny | SEN | Middle LB | 2 | 12 |
| Chris Long | PHN | Right End | 2 | 12 |
| Kyle Williams | PHN | Right Tackle | 2 | 12 |
| Barry Cofield | CHN | Left Tackle | 2 | 11 |
| Bryan Thomas | PIA | Left O LB | 2 | 10 |
| Damione Lewis | CHN | Right Tackle | 2 | 9 |
| Tyrell Johnson | OAA | 1st Defensive Back | 2 | 9 |
| Kirk Morrison | SFN | Middle LB | 2 | 9 |
| John Thornton | KCA | Right Tackle | 2 | 8 |
| Ty Warren | TNA | Left End | 2 | 7 |
| Chartric Darby | NYA | Left Tackle | 2 | 6 |
| Aubrayo Franklin | NEA | Nose Tackle | 2 | 6 |
| Isaac Sopoaga | MNN | Left End | 2 | 5 |
| Andra Davis | PHN | Left I LB | 2 | 5 |
| Vince Wilfork | SDA | Nose Tackle | 2 | 4 |
| Casey Hampton | PIA | Nose Tackle | 2 | 3 |
| Cory Redding | NON | Right Tackle | 2 | 3 |
| Jamal Williams | GBN | Nose Tackle | 2 | 3 |
| Antonio Pierce | KCA | Middle LB | 2 | 0 |
| Jimmy Wilkerson | SFN | Def End | 1 | 12 |
| Pisa Tinoisamoa | NEA | Right LB | 1 | 12 |
| Tully Banta-Cain | PHN | O LB | 1 | 11 |
| Jonathan Vilma | JXA | Middle LB | 1 | 11 |
| Jarret Johnson | GBN | Left O LB | 1 | 11 |
| Dewayne Robertson | SEN | Left Tackle | 1 | 10 |
| Willie McGinest | DAN | Left O LB | 1 | 10 |
| Stephen Cooper | MNN | Left I LB | 1 | 10 |
| D.J. Williams | ATN | Right LB | 1 | 9 |
| Abram Elam | MNN | Strong Safety | 1 | 9 |
| Glenn Dorsey | BAA | Right Tackle | 1 | 9 |
| Aaron Ross | NEA | Left CB | 1 | 9 |
| Josh Bullocks | MNN | 1st Defensive Back | 1 | 8 |
| Justin Bannan | SFN | Right End | 1 | 8 |
| Kamerion Wimbley | SLN | Right O LB | 1 | 8 |
| DeMeco Ryans | SDA | Middle LB | 1 | 8 |
| Travis LaBoy | OAA | Right End | 1 | 8 |
| Chris Clemons | BFA | Def End | 1 | 8 |
| Kenyon Coleman | PHN | Right End | 1 | 8 |
| Derrick Harvey | NYA | Left End | 1 | 8 |
| Takeo Spikes | HOA | Left I LB | 1 | 8 |
| Sean Considine | DAN | 1st Defensive Back | 1 | 7 |
| Chad Greenway | NYA | Left LB | 1 | 7 |
| Jason Taylor | DEN | Def End | 1 | 7 |
| Mike Patterson | HOA | Left Tackle | 1 | 7 |
| Mathias Kiwanuka | NEA | Right End | 1 | 7 |
| Shaun Smith | PIA | Right End | 1 | 7 |
| Donte Whitner | NYN | Free Safety | 1 | 7 |
| Patrick Willis | BFA | Right I LB | 1 | 7 |
| Phillip Buchanon | HOA | Left CB | 1 | 7 |
| Brett Keisel | BFA | Right End | 1 | 7 |
| Chris Houston | NON | Right CB | 1 | 6 |
| Champ Bailey | CHN | Left CB | 1 | 6 |
| Gerard Warren | SFN | Left Tackle | 1 | 6 |
| Will Smith | TNA | Right End | 1 | 6 |
| Cornelius Griffin | ATN | Left Tackle | 1 | 6 |
| David Jones | TBN | 1st Defensive Back | 1 | 6 |
| Ben Leber | PHN | Right LB | 1 | 6 |
| Anthony Spencer | SLN | O LB | 1 | 6 |
| Reggie Hayward | ATN | Right End | 1 | 5 |
| Trevor Pryce | SDA | Left End | 1 | 5 |
| Travis Kirschke | SEN | Def End | 1 | 5 |
| Terrence McGee | SDA | Left CB | 1 | 5 |
| Antonio Smith | NYA | Left End | 1 | 4 |
| Charles Godfrey | PHN | Free Safety | 1 | 4 |
| Chase Blackburn | NYN | Right LB | 1 | 4 |
| Chris Kelsay | DAN | Left End | 1 | 3 |
| Domata Peko | DAN | Left Tackle | 1 | 3 |
| Kendrick Clancy | DEN | Left Tackle | 1 | 3 |
| Jacob Ford | TNA | Def End | 1 | 2 |
| Israel Idonije | DAN | Def End | 1 | 2 |
| Mike Vrabel | DEN | Left O LB | 1 | 2 |
| Dhani Jones | GBN | Middle LB | 1 | 1 |
| David Harris | TNA | Right I LB | 1 | 1 |
| Napoleon Harris | MNN | Middle LB | 1 | 1 |
| Jerrod Mayo | DEN | Left I LB | 1 | 0 |
| Demetric Evans | KCA | Left End | 1 | 0 |
| Ray Lewis | GBN | Left I LB | 1 | 0 |
| Lawrence Timmons | CHN | LB | 1 | 0 |
| London Fletcher | ATN | Middle LB | 1 | 0 |
| Zach Thomas | BAA | Right I LB | 1 | 0 |
| Sum | --- | --- | 500 | 3176 |
| Avg | --- | --- | 3 | 19 |