Player - Rushing
| NameFL | TAbb | RushA | RushY | RushAvg | RushL | RushTDs | Rush1stD | Rush3rdA1FD | Rush3rd1A | FumTot | FumLost |
| Adrian L. Peterson | JAX | 469 | 2133 | 4.5 | 67 | 8 | 109 | 2 | 3 | 17 | 9 |
| Brandon Jacobs | ARI | 358 | 2023 | 5.7 | 36 | 14 | 103 | 5 | 5 | 1 | 0 |
| Steven Jackson | MIN | 395 | 1987 | 5.0 | 56 | 12 | 102 | 8 | 11 | 7 | 2 |
| Chris D. Johnson | SDI | 347 | 1753 | 5.1 | 66 | 12 | 80 | 1 | 3 | 0 | 0 |
| Derrick Ward | SFR | 308 | 1744 | 5.7 | 51 | 18 | 78 | 4 | 8 | 1 | 1 |
| Clinton Portis | NEE | 355 | 1743 | 4.9 | 31 | 14 | 92 | 5 | 5 | 3 | 0 |
| Steve Slaton | BAL | 338 | 1665 | 4.9 | 77 | 14 | 71 | 4 | 5 | 0 | 0 |
| DeAngelo Williams | NYG | 265 | 1587 | 6.0 | 66 | 13 | 68 | 0 | 1 | 1 | 0 |
| Warrick Dunn | STL | 309 | 1374 | 4.4 | 40 | 2 | 57 | 4 | 5 | 2 | 0 |
| Ryan Grant | DAL | 334 | 1374 | 4.1 | 40 | 10 | 72 | 2 | 3 | 0 | 0 |
| Ricky Williams | CHI | 242 | 1328 | 5.5 | 51 | 4 | 54 | 0 | 1 | 8 | 4 |
| Maurice Jones-Drew | CLE | 252 | 1313 | 5.2 | 46 | 3 | 59 | 4 | 5 | 13 | 6 |
| Sammy Morris | HOU | 271 | 1297 | 4.8 | 35 | 5 | 77 | 0 | 0 | 0 | 0 |
| Frank Gore | SEA | 267 | 1233 | 4.6 | 41 | 10 | 65 | 2 | 3 | 5 | 2 |
| Matt Forte' | GBA | 303 | 1138 | 3.8 | 36 | 9 | 57 | 2 | 3 | 4 | 3 |
| Brian Westbrook | IND | 269 | 1125 | 4.2 | 39 | 9 | 65 | 2 | 3 | 0 | 0 |
| Marshawn Lynch | NYJ | 233 | 1103 | 4.7 | 50 | 5 | 57 | 1 | 2 | 0 | 0 |
| LaDainian Tomlinson | PHI | 291 | 1096 | 3.8 | 36 | 3 | 42 | 0 | 1 | 4 | 1 |
| Willie Parker | MIA | 257 | 1089 | 4.2 | 27 | 3 | 58 | 1 | 1 | 2 | 0 |
| Le'Ron McClain | OAK | 218 | 1082 | 5.0 | 27 | 1 | 52 | 3 | 4 | 3 | 1 |
| Pierre Thomas | DET | 195 | 1066 | 5.5 | 37 | 8 | 53 | 1 | 3 | 3 | 2 |
| Ronnie Brown | CIN | 225 | 947 | 4.2 | 22 | 5 | 44 | 4 | 5 | 0 | 0 |
| Jonathan Stewart | CLE | 211 | 927 | 4.4 | 35 | 3 | 49 | 1 | 2 | 0 | 0 |
| Willis McGahee | CAR | 216 | 913 | 4.2 | 27 | 8 | 58 | 4 | 5 | 5 | 0 |
| Thomas Jones | CIN | 188 | 818 | 4.4 | 51 | 7 | 35 | 0 | 2 | 1 | 1 |
| Correll Buckhalter | BUF | 174 | 770 | 4.4 | 27 | 1 | 35 | 0 | 0 | 0 | 0 |
| Ray Rice | CAR | 172 | 709 | 4.1 | 38 | 4 | 37 | 1 | 2 | 0 | 0 |
| Cedric Benson | OAK | 167 | 701 | 4.2 | 46 | 5 | 34 | 1 | 3 | 2 | 2 |
| Michael Pittman | DET | 156 | 659 | 4.2 | 19 | 4 | 37 | 3 | 4 | 0 | 0 |
| Larry Johnson | GBA | 138 | 630 | 4.6 | 22 | 6 | 36 | 1 | 3 | 3 | 2 |
| Tashard Choice | SEA | 126 | 628 | 5.0 | 38 | 3 | 43 | 2 | 3 | 0 | 0 |
| Ahmad Bradshaw | NYJ | 103 | 571 | 5.5 | 31 | 1 | 28 | 0 | 0 | 5 | 3 |
| Reggie Bush | CHI | 108 | 538 | 5.0 | 43 | 3 | 25 | 0 | 0 | 1 | 1 |
| Fred Taylor | BUF | 136 | 534 | 3.9 | 33 | 4 | 25 | 0 | 0 | 0 | 0 |
| Maurice Morris | SFR | 121 | 508 | 4.2 | 28 | 4 | 29 | 0 | 0 | 1 | 0 |
| Fred Jackson | DAL | 82 | 469 | 5.7 | 24 | 1 | 24 | 0 | 0 | 0 | 0 |
| Mewelde Moore | MIA | 132 | 444 | 3.4 | 32 | 6 | 31 | 3 | 5 | 2 | 2 |
| Ahman Green | ARI | 97 | 425 | 4.4 | 13 | 4 | 29 | 1 | 2 | 0 | 0 |
| Jerious Norwood | DAL | 72 | 401 | 5.6 | 45 | 0 | 17 | 0 | 0 | 1 | 0 |
| Joseph Addai | IND | 77 | 328 | 4.3 | 18 | 2 | 18 | 0 | 2 | 1 | 1 |
| Kevin Faulk | PHI | 72 | 319 | 4.4 | 18 | 1 | 13 | 0 | 0 | 3 | 1 |
| Tyler Thigpen | CHI | 81 | 311 | 3.8 | 32 | 0 | 20 | 4 | 5 | 6 | 2 |
| Peyton Hillis | BUF | 63 | 306 | 4.9 | 18 | 0 | 14 | 0 | 0 | 0 | 0 |
| Julius Jones | MIN | 89 | 303 | 3.4 | 29 | 2 | 16 | 0 | 1 | 2 | 1 |
| Jamal Lewis | DET | 59 | 293 | 5.0 | 29 | 7 | 21 | 2 | 3 | 1 | 1 |
| LenDale White | NEE | 105 | 286 | 2.7 | 21 | 2 | 21 | 6 | 6 | 0 | 0 |
| Joe Flacco | STL | 73 | 257 | 3.5 | 38 | 2 | 15 | 2 | 2 | 11 | 6 |
| Darren McFadden | STL | 76 | 247 | 3.3 | 27 | 1 | 13 | 0 | 1 | 4 | 4 |
| Ryan Fitzpatrick | HOU | 59 | 234 | 4.0 | 22 | 3 | 17 | 5 | 6 | 14 | 3 |
| Justin Fargas | OAK | 73 | 232 | 3.2 | 15 | 3 | 11 | 0 | 1 | 0 | 0 |
| Earnest Graham | CHI | 53 | 194 | 3.7 | 47 | 4 | 13 | 0 | 0 | 1 | 1 |
| Michael Bush | HOU | 69 | 182 | 2.6 | 18 | 0 | 4 | 0 | 1 | 1 | 0 |
| Matt Cassel | DAL | 43 | 177 | 4.1 | 18 | 3 | 14 | 3 | 3 | 2 | 0 |
| Aaron Rodgers | PHI | 67 | 176 | 2.6 | 11 | 3 | 19 | 4 | 6 | 11 | 7 |
| Seneca Wallace | IND | 42 | 172 | 4.1 | 17 | 2 | 12 | 3 | 5 | 5 | 1 |
| Jason Campbell | SFR | 48 | 154 | 3.2 | 23 | 2 | 11 | 1 | 1 | 2 | 2 |
| Josh Cribbs | OAK | 40 | 139 | 3.5 | 11 | 0 | 6 | 0 | 0 | 0 | 0 |
| Marion Barber III | NYJ | 37 | 132 | 3.6 | 25 | 3 | 12 | 0 | 1 | 0 | 0 |
| Edgerrin James | CIN | 30 | 115 | 3.8 | 35 | 0 | 3 | 0 | 0 | 0 | 0 |
| Donovan McNabb | BUF | 32 | 110 | 3.4 | 17 | 1 | 9 | 2 | 2 | 1 | 1 |
| Carson Palmer | GBA | 28 | 108 | 3.9 | 15 | 1 | 8 | 2 | 2 | 4 | 2 |
| David Garrard | NYJ | 39 | 101 | 2.6 | 13 | 1 | 8 | 0 | 1 | 6 | 3 |
| Chester Taylor | BAL | 36 | 96 | 2.7 | 12 | 4 | 12 | 2 | 3 | 1 | 1 |
| Kenneth Darby | ARI | 34 | 95 | 2.8 | 14 | 5 | 11 | 0 | 0 | 1 | 1 |
| Tony Richardson | NYG | 25 | 91 | 3.6 | 16 | 5 | 13 | 0 | 1 | 0 | 0 |
| Ben Roethlisberger | OAK | 36 | 77 | 2.1 | 17 | 1 | 7 | 0 | 0 | 11 | 8 |
| Jay Cutler | DET | 28 | 76 | 2.7 | 12 | 1 | 4 | 0 | 1 | 3 | 3 |
| Michael Turner | SDI | 31 | 74 | 2.4 | 28 | 6 | 8 | 1 | 6 | 0 | 0 |
| Chad Pennington | CIN | 39 | 70 | 1.8 | 16 | 1 | 12 | 3 | 5 | 4 | 2 |
| Rudi Johnson | STL | 22 | 68 | 3.1 | 9 | 1 | 7 | 1 | 1 | 0 | 0 |
| Montell Owens | NYG | 15 | 63 | 4.2 | 15 | 3 | 5 | 0 | 0 | 0 | 0 |
| Leonard Weaver | SEA | 16 | 63 | 3.9 | 14 | 1 | 5 | 0 | 0 | 0 | 0 |
| Jason Snelling | SFR | 28 | 59 | 2.1 | 8 | 3 | 11 | 1 | 1 | 1 | 1 |
| Matt Schaub | SEA | 38 | 59 | 1.6 | 10 | 1 | 6 | 0 | 1 | 13 | 8 |
| Jeff Garcia | SDI | 20 | 54 | 2.7 | 9 | 0 | 4 | 0 | 1 | 8 | 1 |
| Quinton Ganther | SEA | 8 | 53 | 6.6 | 22 | 0 | 2 | 0 | 0 | 0 | 0 |
| J.T. O'Sullivan | GBA | 10 | 53 | 5.3 | 18 | 1 | 3 | 0 | 1 | 1 | 1 |
| Jerome Harrison | CLE | 20 | 51 | 2.5 | 16 | 0 | 4 | 0 | 0 | 0 | 0 |
| LaMont Jordan | JAX | 23 | 50 | 2.2 | 10 | 3 | 9 | 1 | 3 | 0 | 0 |
| Shaun Hill | JAX | 29 | 44 | 1.5 | 10 | 0 | 5 | 1 | 1 | 18 | 8 |
| Benjarvus Green-Ellis | BUF | 11 | 38 | 3.5 | 14 | 1 | 6 | 1 | 2 | 0 | 0 |
| Larry Fitzgerald | NYJ | 4 | 32 | 8.0 | 41 | 0 | 1 | 0 | 0 | 2 | 0 |
| Tarvaris Jackson | SEA | 4 | 30 | 7.5 | 9 | 0 | 2 | 0 | 0 | 0 | 0 |
| Tim Hightower | MIA | 8 | 29 | 3.6 | 13 | 1 | 2 | 0 | 0 | 0 | 0 |
| Philip Rivers | NYG | 35 | 29 | 0.8 | 10 | 1 | 5 | 1 | 1 | 8 | 4 |
| J.J. Arrington | NEE | 2 | 28 | 14.0 | 19 | 0 | 2 | 0 | 0 | 1 | 1 |
| T.J. Duckett | JAX | 8 | 28 | 3.5 | 12 | 4 | 6 | 0 | 0 | 0 | 0 |
| Drew Brees | BAL | 10 | 27 | 2.7 | 9 | 0 | 5 | 4 | 4 | 1 | 0 |
| Brett Favre | MIN | 34 | 20 | 0.6 | 27 | 0 | 3 | 1 | 1 | 9 | 4 |
| Antonio Bryant | BUF | 2 | 15 | 7.5 | 15 | 0 | 1 | 0 | 0 | 0 | 0 |
| Jon Kitna | HOU | 2 | 14 | 7.0 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
| Ovie Mughelli | DET | 5 | 14 | 2.8 | 9 | 0 | 1 | 0 | 0 | 0 | 0 |
| Tony Romo | CAR | 23 | 13 | 0.6 | 6 | 1 | 2 | 0 | 0 | 16 | 11 |
| DeShaun Foster | BAL | 5 | 12 | 2.4 | 10 | 0 | 2 | 0 | 1 | 1 | 1 |
| Deuce McAllister | CHI | 3 | 11 | 3.7 | 10 | 0 | 1 | 0 | 0 | 0 | 0 |
| Kyle Orton | CIN | 6 | 11 | 1.8 | 7 | 0 | 2 | 0 | 0 | 0 | 0 |
| Cadillac Williams | CHI | 7 | 10 | 1.4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Derek Anderson | OAK | 2 | 9 | 4.5 | 9 | 0 | 1 | 0 | 0 | 1 | 0 |
| Jason McKie | ARI | 2 | 9 | 4.5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brandon Jackson | NYJ | 3 | 8 | 2.7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kevin Jones | NYG | 5 | 8 | 1.6 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lousaka Polite | CIN | 7 | 8 | 1.1 | 3 | 1 | 3 | 1 | 1 | 0 | 0 |
| Adrian Peterson | HOU | 3 | 7 | 2.3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Chris Perry | BUF | 3 | 6 | 2.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Matt Ryan | DET | 1 | 5 | 5.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ladell Betts | CAR | 5 | 5 | 1.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peyton Manning | NEE | 10 | 5 | 0.5 | 8 | 0 | 0 | 0 | 0 | 5 | 2 |
| Lawrence Vickers | OAK | 3 | 4 | 1.3 | 3 | 2 | 2 | 0 | 0 | 0 | 0 |
| Jake Delhomme | CLE | 17 | 4 | 0.2 | 5 | 2 | 6 | 3 | 6 | 2 | 1 |
| David Carr | NEE | 1 | 3 | 3.0 | 3 | 0 | 0 | 0 | 0 | 1 | 0 |
| Byron Leftwich | CLE | 4 | 3 | 0.8 | 5 | 0 | 1 | 0 | 0 | 0 | 0 |
| Vonta Leach | PHI | 2 | 1 | 0.5 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| Heath Evans | BUF | 2 | 1 | 0.5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kurt Warner | ARI | 14 | 1 | 0.1 | 5 | 0 | 1 | 1 | 1 | 3 | 3 |
| Tatum Bell | STL | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Deon Anderson | STL | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Marques Colston | HOU | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mike Cox | HOU | 2 | 0 | 0.0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 |
| DeShawn Wynn | OAK | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Sage Rosenfels | PHI | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Jim Sorgi | ARI | 3 | -1 | -0.3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Korey Hall | CAR | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Brian Griese | NYG | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kerry Collins | DAL | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Troy Smith | SFR | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Moran Norris | DAL | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| B.J. Askew | CLE | 1 | -2 | -2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Braylon Edwards | NEE | 1 | -4 | -4.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Felix Jones | IND | 6 | -5 | -0.8 | 3 | 0 | 2 | 1 | 1 | 1 | 0 |
| Torry Holt | JAX | 2 | -6 | -3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Wes Welker | JAX | 3 | -7 | -2.3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Michael Clayton | CLE | 2 | -7 | -3.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| JaMarcus Russell | SDI | 8 | -8 | -1.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Eli Manning | MIA | 10 | -9 | -0.9 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
| Plaxico Burress | JAX | 2 | -9 | -4.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Santana Moss | BUF | 2 | -14 | -7.0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Sum | --- | 11018 | 48287 | --- | 2614 | 340 | 2573 | 129 | 204 | 289 | 142 |
| Avg | --- | 81 | 355 | --- | 19 | 3 | 19 | 1 | 2 | 2 | 1 |