Player - Sacks
| NameFL | TAbb | PosN | Sack | SackYds |
| Dwight Freeney | SDI | Right End | 12 | 91 |
| Fred Robbins | MIN | Right Tackle | 10 | 62 |
| Shaun Rogers | OAK | Nose Tackle | 9 | 44 |
| Cory Redding | SDI | Right Tackle | 9 | 37 |
| Shaun Phillips | NEE | Left O LB | 8 | 55 |
| DeMarcus Ware | DAL | Right O LB | 7 | 54 |
| Parys Haralson | STL | Right O LB | 7 | 49 |
| LaMarr Woodley | STL | Left O LB | 7 | 47 |
| Justin Tuck | PHI | Left End | 7 | 46 |
| Marcus Stroud | BUF | Left Tackle | 7 | 37 |
| Ray Edwards | SDI | Left End | 6 | 49 |
| Leonard Little | MIA | Def End | 6 | 45 |
| Alex Brown | ARI | Right End | 6 | 45 |
| James Hall | CAR | Def End | 6 | 43 |
| Albert Haynesworth | GBA | Right Tackle | 6 | 42 |
| Kevin Williams | IND | Right Tackle | 6 | 41 |
| Karlos Dansby | BUF | Right LB | 6 | 40 |
| Manny Lawson | SDI | Left O LB | 6 | 38 |
| Kamerion Wimbley | PHI | Right O LB | 6 | 36 |
| Demetric Evans | STL | Left End | 6 | 32 |
| Derrick Burgess | CIN | Right End | 5 | 42 |
| Tommie Harris | NYG | Left Tackle | 5 | 37 |
| Jared Allen | BUF | Right End | 5 | 35 |
| Dewayne White | SFR | Right End | 5 | 35 |
| Terrell Suggs | OAK | Right O LB | 5 | 33 |
| Joey Porter | CIN | Right O LB | 5 | 31 |
| Mike Vrabel | GBA | Left O LB | 5 | 29 |
| Mario Williams | NYJ | Right End | 5 | 29 |
| Chase Blackburn | SDI | Right LB | 5 | 26 |
| Leroy Hill | SFR | Left LB | 4 | 38 |
| Charles Grant | MIN | Left End | 4 | 29 |
| Trent Cole | DAL | Right End | 4 | 27 |
| James Harrison | DAL | Right O LB | 4 | 26 |
| Jay Ratliff | CHI | Nose Tackle | 4 | 24 |
| Vince Wilfork | SFR | Nose Tackle | 4 | 24 |
| Bart Scott | PHI | Right I LB | 4 | 22 |
| John Abraham | DET | Right End | 4 | 21 |
| A.J. Hawk | BUF | Right LB | 4 | 21 |
| Aaron Kampman | SEA | Left End | 4 | 21 |
| Donte Whitner | SDI | Free Safety | 4 | 20 |
| Aaron Smith | CIN | Left End | 3 | 26 |
| Victor Abiamiri | CAR | Def End | 3 | 24 |
| Jevon Kearse | DAL | Left End | 3 | 22 |
| Matt Roth | MIN | Left O LB | 3 | 22 |
| Keith Bulluck | PHI | Right LB | 3 | 21 |
| Julian Peterson | CIN | Right LB | 3 | 18 |
| John Henderson | MIN | Left Tackle | 3 | 18 |
| Quentin Groves | NYG | Def End | 3 | 18 |
| Darnell Dockett | CLE | Right Tackle | 3 | 17 |
| Mike Patterson | CLE | Left Tackle | 3 | 17 |
| Domata Peko | SDI | Left Tackle | 3 | 17 |
| Ray Lewis | CAR | Left I LB | 3 | 15 |
| Haloti Ngata | JAX | Nose Tackle | 3 | 5 |
| Kirk Morrison | SFR | Middle LB | 3 | 5 |
| Darren Howard | OAK | Def End | 2 | 19 |
| Igor Olshansky | CLE | Left End | 2 | 18 |
| Chad Greenway | SFR | Left LB | 2 | 18 |
| Grady Jackson | CAR | Left Tackle | 2 | 17 |
| Greg Ellis | JAX | Left O LB | 2 | 14 |
| Chris Canty | CLE | Right End | 2 | 14 |
| Kalimba Edwards | HOU | Left End | 2 | 14 |
| Ryan Clark | NEE | Free Safety | 2 | 14 |
| Chike Okeafor | ARI | Left LB | 2 | 14 |
| Juqua Parker | MIN | Left End | 2 | 13 |
| Kevin Carter | GBA | Left End | 2 | 13 |
| Calvin Pace | CLE | Right O LB | 2 | 13 |
| Chris Long | ARI | Right End | 2 | 12 |
| Gibril Wilson | PHI | Strong Safety | 2 | 12 |
| Jeremy Clark | DAL | Def Tackle | 2 | 11 |
| Trevor Pryce | NEE | Left End | 2 | 11 |
| Dewayne Robertson | PHI | Left Tackle | 2 | 11 |
| Brandon Mebane | BAL | Left Tackle | 2 | 10 |
| Julius Peppers | BUF | Right End | 2 | 10 |
| Shaun Ellis | IND | Left End | 2 | 9 |
| Jonathan Babineaux | ARI | Right Tackle | 2 | 9 |
| Raheem Brock | NYJ | Left End | 2 | 9 |
| Gaines Adams | CAR | Right End | 2 | 9 |
| Sedrick Ellis | STL | Right Tackle | 2 | 9 |
| David Harris | IND | Right I LB | 2 | 8 |
| Tony Brown | NEE | Left Tackle | 2 | 8 |
| Kendrick Clancy | SDI | Left Tackle | 2 | 7 |
| Larry Foote | CIN | Right I LB | 2 | 7 |
| Victor Adeyanju | CHI | Left End | 2 | 7 |
| D'Qwell Jackson | SDI | Right I LB | 2 | 7 |
| Rocky Bernard | HOU | Right Tackle | 2 | 7 |
| Jerrod Mayo | NEE | Left I LB | 2 | 5 |
| Antonio Pierce | JAX | Middle LB | 2 | 0 |
| Troy Polamalu | BUF | Strong Safety | 1 | 12 |
| Will Smith | PHI | Right End | 1 | 12 |
| Kawika Mitchell | CHI | Left LB | 1 | 11 |
| Charles Woodson | OAK | Left CB | 1 | 10 |
| Jamie Winborn | BUF | Left LB | 1 | 10 |
| Adrian Wilson | JAX | Strong Safety | 1 | 10 |
| Justin Bannan | SFR | Right End | 1 | 9 |
| Derrick Brooks | SEA | Right LB | 1 | 8 |
| Ike Taylor | DAL | Left CB | 1 | 8 |
| Cliff Avril | DAL | Def End | 1 | 8 |
| Roman Harper | SDI | Strong Safety | 1 | 8 |
| Lawrence Timmons | NYJ | LB | 1 | 8 |
| Richard Seymour | MIA | Right End | 1 | 8 |
| Anthony Spencer | CLE | O LB | 1 | 8 |
| Kevin Kaesviharn | STL | Free Safety | 1 | 8 |
| Kroy Biermann | STL | LB | 1 | 8 |
| Jameel McClain | IND | O LB | 1 | 8 |
| Reggie Hayward | SFR | Right End | 1 | 8 |
| Chauncey Davis | DET | Def End | 1 | 8 |
| Samari Rolle | NYJ | Left CB | 1 | 8 |
| Chris Johnson | NYJ | Right CB | 1 | 7 |
| Shaun Smith | JAX | Right End | 1 | 7 |
| Nnamdi Asomugha | SFR | Left CB | 1 | 7 |
| Adalius Thomas | MIA | Right O LB | 1 | 7 |
| Justin Smith | BAL | Right End | 1 | 7 |
| Greg White | NEE | Def End | 1 | 7 |
| Landon Johnson | SFR | LB | 1 | 6 |
| D.D. Lewis | SEA | LB | 1 | 6 |
| Daryl Smith | MIA | Middle LB | 1 | 6 |
| Rocky McIntosh | NYJ | Right LB | 1 | 6 |
| Barry Cofield | DET | Left Tackle | 1 | 6 |
| Danny Clark | MIA | Left LB | 1 | 6 |
| Ty Warren | GBA | Left End | 1 | 6 |
| Chris Hope | DAL | Strong Safety | 1 | 6 |
| Thomas Howard | SEA | Left LB | 1 | 6 |
| Mike Peterson | GBA | Middle LB | 1 | 5 |
| John Thornton | GBA | Right Tackle | 1 | 5 |
| DeMeco Ryans | DAL | Middle LB | 1 | 5 |
| Adewale Ogunleye | SEA | Left End | 1 | 5 |
| Kerry Rhodes | NYJ | Free Safety | 1 | 5 |
| Bryan Thomas | DET | Left O LB | 1 | 5 |
| Brandon Johnson | PHI | Right LB | 1 | 5 |
| Anthony Henry | GBA | Right CB | 1 | 5 |
| Jarret Johnson | OAK | Left O LB | 1 | 5 |
| Terence Newman | CAR | Left CB | 1 | 5 |
| Takeo Spikes | CLE | Left I LB | 1 | 5 |
| Cato June | MIN | Left LB | 1 | 5 |
| Trevor Laws | PHI | Def Tackle | 1 | 4 |
| Thomas Davis | NYG | Right LB | 1 | 4 |
| Ronald Bartell | SFR | Left CB | 1 | 4 |
| Michael Johnson | ARI | Free Safety | 1 | 4 |
| Vonnie Holliday | IND | Right End | 1 | 4 |
| Jamaal Anderson | NYG | Left End | 1 | 4 |
| Andre' Goodman | BUF | Right CB | 1 | 4 |
| Morlon Greenwood | HOU | Right LB | 1 | 3 |
| D.J. Williams | NYJ | Right LB | 1 | 3 |
| Luis Castillo | BAL | Right End | 1 | 3 |
| Dunta Robinson | BUF | Right CB | 1 | 3 |
| Dusty Dvoracek | BUF | Right Tackle | 1 | 2 |
| Barrett Ruud | BAL | Middle LB | 1 | 2 |
| Chris Hovan | CAR | Left Tackle | 1 | 2 |
| Eric Barton | OAK | Left I LB | 1 | 1 |
| Jason Ferguson | ARI | Nose Tackle | 1 | 0 |
| Gerald Hayes | CHI | Middle LB | 1 | 0 |
| Ryon Bingham | NYJ | Def End | 1 | 0 |
| Casey Hampton | SEA | Nose Tackle | 1 | 0 |
| Jon Beason | ARI | Middle LB | 1 | 0 |
| Kris Jenkins | MIA | Nose Tackle | 1 | 0 |
| Jovan Haye | DAL | Right Tackle | 1 | 0 |
| Sione Pouha | PHI | Nose Tackle | 1 | 0 |
| Sum | --- | --- | 410 | 2488 |
| Avg | --- | --- | 3 | 16 |